新疆紫草中1个新的紫草呋喃类化合物

A new shikonofuran compound from Arnebia euchroma

目的研究新疆紫草Arnebiaeuchroma的化学成分。方法运用硅胶柱色谱、MCI凝胶柱色谱、SephadexLH-20柱色谱及制备型HPLC等方法进行分离纯化,通过核磁共振、质谱等波谱学方法并结合文献对分离得到的化合物进行结构鉴定。结果从该植物干燥根的75%乙醇提取物中分离纯化得到3个化合物,分别鉴定为2-(2′-烯基-4′-羟基-环己酮-3′-基)-4-(1′′-羟基-4′′-甲基-3′′-戊烯-1′′-基)呋喃(1)、arnebinol A(2)和arnebinol C(3)。结论化合物1为新的紫草呋喃类化合物,命名为紫草呋喃萜酮A。

Objective To study the chemical constituents from the roots of Arnebia euchroma. Methods The chemical constituents were isolated and purified by silica gel, MCI gel, Sephadex LH-20 column chromatography and preparative HPLC. The structures of the isolated compounds were identified by NMR and MS spectroscopic methods. Results Three compounds(1-3) were isolated from the 75% ethanol extract of A. euchroma, and identified as 2-(2′-ene-4′-hydroxy-cyclohexanone-3′-)-4-(1′′-hydroxy-4′′-methyl-3′′-pentene-1′′-) furan(1), arnebinol A(2) and arnebinol C(3). Conclusion Compound 1 is a new shikonofuran compound named shikonofuranone A.