基于数据挖掘的维吾尔医药治疗骨伤科用药规律研究分析

Research and analysis on medication rule of Uygur Medicine in treatment of orthopedics and traumatology based on data mining

目的通过研究维吾尔族医药治疗骨伤科的用药规律,为中医药防治骨伤科疾病提供参考。方法以《中华本草·维吾尔药卷》《中国医学百科全书·维医学》以及CNKI、维普数据库、万方数据库为数据来源,选取符合标准的文献及方药,采用Office Excel 2019、SPSS Modeler 14、IBM SPSS Statistics 20.0统计软件,进行统计学处理及关联规则分析。结果共筛选验方(含单方)209条,其中内服方120条,外用方89条,涉及342味药物及骨伤科常见痹证关节疼痛、肌痹、腰痛(痹)3种疾病。内服药常见的高频药物有小茴香、玫瑰花、干姜、秋水仙、肉桂、荜茇、胡椒、番泻叶、芹菜子;外用药常见的高频药物有秋水仙、除虫菊根、玫瑰花、巴旦杏仁、洋甘菊、荜茇、芸香、芦荟、石菖蒲。内服药及外用药均以温性药为主,药味均为辛、甘、苦,内服药物多数归脾、胃、肝、肾经,外用药多数归肺、肝、大肠经。在聚类分析中,内服和外用药均获得4类用药聚类组合。关联规则分析中,内服药以温里药、理气药为主,常配伍清热药、祛风湿药;外用药以清热药、祛风湿药、理气药为主。结论维医药治疗骨伤科常见痹证多用辛温、甘温、苦温药物,常选用温里药、理气药、清热药、祛风湿药,以促进致病体液成熟并清除痹证的黏液质体液,体现了维医药的致病体液成熟和致病体液排泻治疗原则。

Objective To investigate the medication rules of Uygur Medicine in the treatment of orthopedic diseases, so as to provide reference for the prevention and treatment of orthopedic diseases with traditional Chinese medicine. Methods Based on Chinese materia medica-Uyghur Medicine volume, Chinese Medical Encyclopedia-Uyghur Medicine, CNKI, VIP database and Wanfang database, the standard literatures and prescriptions were selected, and the statistical processing and association rules were analyzed by using Office Excel 2019, SPSS Modeler 14 and IBM SPSS Statistics 20.0 statistical software. Results A total of 209 prescriptions(including single prescription) were screened, including 120 prescriptions for internal use and 89 prescriptions for external use, involving 342 kinds of drugs and three common diseases of arthralgia, myalgia and lumbago in orthopedics. The common high-frequency drugs for internal use are Xiaohuixiang(Foeniculi Fructus), Meiguihua(Rosae Rugosae Flos), Ganjiang(Zingiberis Rhizoma), Qiushuixian(Colchicum autumnale L.), Rougui(Cinnamomi Cortex), Biba(Piperis Longi Fructus), Hujiao(Piperis Fructus), Fanxieye(Sennae Folium) and Qincaizi(seed of Apium graveolens L.);the common high-frequency drugs for external use are Colchicum autumnale, Chuchongjugen(root of Pyrethrum cinerariifolium Trev.), Rosae Rugosae Flos, Badaxingren(seed of Amygdalus communis L.), Yangganju(Matricaria chamomilla L.), Piperis Longi Fructus, Yunxiang(Ruta graveolens L.), Luhui(Aloe) and Shichangpu(Acori Tatarinowii Rhizoma). Both internal and external drugs were mainly warm drugs, with bitter, sweet and sweet flavors. Most of the drugs for internal use attribute to spleen, stomach, liver and kidney meridians, while most of the drugs for external use attribute to lung, liver and large intestine meridians. In the cluster analysis, four cluster combinations were obtained for internal medicine and four cluster combinations were obtained for external medicine. In the analysis of association rules, the drugs for internal use are mainly warming drugs and regulating qi drugs, which are often combined with heat clearing drugs and wind dampness removing drugs;the drugs for external use are mainly heat clearing drugs, wind dampness removing drugs and regulating qi drugs. Conclusion Uyghur Medicine usually uses warm, sweet and bitter drugs in the treatment of common arthralgia syndrome in orthopedics and traumatology department, and often uses interior-warming drugs, qi regulating drugs, heat clearing drugs and wind dampness eliminating drugs to promote the maturation of pathogenic body fluid and remove the mucinous fluid of arthralgia syndrome, which reflects the treatment principle of Uyghur Medicine for the maturation of pathogenic body fluid and remove of pathogenic body fluid.