从马兜铃内酰胺探讨鱼腥草安全性

Safety discussion of Houttuyniae Herba based on aristololactam

鱼腥草是常见的药食同源植物,具有数千年的食用、药用历史,现有研究表明,鱼腥草安全无毒。但由于鱼腥草含有马兜铃内酰胺成分,其安全性一直存在较多争议,而关于鱼腥草中马兜铃内酰胺毒性的探讨并不多见。从鱼腥草中马兜铃内酰胺的构效关系、量效关系、实验研究等方面对鱼腥草的安全性进行探讨,为鱼腥草的食品药品开发及应用提供参考。

Yuxingcao(Houttuyniae Herba) is a common medicine and food homologous plant with a long history of thousands of years. Current studies show that Houttuyniae Herba is safe and non-toxic. However, its safety has been controversial due to aristololactam contained in Houttuyniae Herba, and the toxicity of aristololactam in Houttuyniae Herba is rarely discussed. The safety of aristololactam in Houttuyniae Herba were systematically reviewed from the structure-activity relationship, dose-response relationship and experimental researches in this paper, which could promote the development and application of food and drug containing Houttuyniae Herba.