细颗粒物长期暴露对高血压影响的荟萃分析与系统评价

The effects of long-term exposure to fine particulate matter on hypertension:a meta-analysis and system review

目的系统评价长期暴露于细颗粒物(PM2.5)空气污染对成人高血压发病风险的影响。方法通过检索中国知网、万方数据库、PubMed、Embase、Cochrane Library等数据库中发表的PM2.5长期暴露对高血压影响的队列研究(以上文献检索截至2020年11月)。提取风险比(HR)及其95%CI以评估关联的强度,还进行了亚组分析和敏感性分析。结果最终共有7项研究被纳入分析,总体荟萃分析发现长期PM2.5暴露导致高血压的发病风险增加,每增加10μg/m^(3)暴露浓度HR=1.11,95%CI 1.05~1.17。通过亚组分析发现,年龄≥50岁人群和绝经后女性可能是长期PM2.5暴露导致高血压的高危人群,但本研究没有发现中国和北美地区人群、不同性别的人群在该发病风险上有差异。结论长期PM2.5暴露和高血压的发生存在正相关。

Objective To systematically evaluate the effect of long-term exposure to fine particulate air pollution on the incidence of hypertension in adults.Methods The cohort studies on the effects of long-term exposure to fine paticulate matter(PM2.5)on hypertension published in China national knowledge infrastructure(CNKI),Wanfang database,PubMed,Embase,Cochrane Library and other databases were searched(the literature retrieval was up to November 2020).Hazard ratio(HR)and its 95%CI were extracted to assess the strength of the association.Subgroup analysis and sensitivity analysis were also performed.Results Seven studies were finally included in the analysis.The overall meta-analysis found that long-term exposure to PM2.5 increased the risk of hypertension,HR=1.11,95%CI 1.05-1.17 for each 10μg/m^(3)increase in exposure concentration.Subgroup analysis showed that the elder(≥50 years old)and menopause people may be the high-risk group,and there was no significant difference in the risk of hypertension caused by long-term PM2.5 exposure between Chinese and North American populations and different gender groups.Conclusion There is a positive correlation between long-term PM2.5 exposure and the occurrence of hypertension.