摘要
中性粒细胞绝对值为0的暴发型再生障碍性贫血(FAA)使用免疫抑制治疗(IST)效果欠佳,一线选择异基因造血干细胞移植(allo-HSCT)可能更好;输血依赖型非严重型再生障碍性贫血(TD-NSAA)易进展为严重型AA(SAA),IST较单用环孢菌素(CsA)治疗则更易见效;老年SAA需根据年龄、合并症等分层给予IST联合艾曲泊帕等促血小板生成素激动剂治疗。
The efficacy of immunosuppressive treatment(IST)in fulminant aplastic anemia(SAA)with absolute neutrophil value of 0 is not good,and allogeneic hematopoietic stem cell transplantation(allo HSCT)might improve the outcomes of patients;Transfusion dependent non severe aplastic anemia(TD-NSAA)progress to severe AA(SAA)forwardly,and IST could works better than CsA alone for TD-NSAA;Elderly SAA should be treated with IST combined with hrombopoietin receptor agonist according to age and complications.
作者
何广胜
HE Guang-sheng(Department of Hematology,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Province Hospital,Nanjing 210029,China)
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2021年第10期836-838,共3页
Chinese Journal of Practical Internal Medicine
基金
卫生公益性行业科研专项经费项目(201202017)
江苏省研究型医院学会贫血专项科研基金。
关键词
再生障碍性贫血
分型
免疫抑制治疗
aplastic anemia
classification
immunosuppressive therapy
