乙哌立松联合普瑞巴林治疗早期枕神经痛的临床效果观察

Clinical effect of eperisone combined with pregabalin on the treatment of early occipital neuralgia

目的探讨乙哌立松联合普瑞巴林治疗早期枕神经痛的临床效果。方法选取2020年10月至2021年6月就诊于首都医科大学电力教学医院的枕神经痛患者120例,采用随机数字表法分为对照组和观察组,各60例。对照组给予常规治疗联合普瑞巴林胶囊治疗,观察组在对照组的治疗基础上联合盐酸乙哌立松片治疗,2组均连续治疗2周。比较2组治疗前和治疗1、2周后的疼痛视觉模拟量表(VAS)评分和头痛影响测试问卷6(HIT-6)评分,以及临床疗效和不良反应发生率。结果治疗1、2周后,2组VAS评分和HIT-6评分均低于治疗前,治疗2周后均低于治疗1周后,且观察组治疗1、2周后VAS评分和HIT-6评分均低于对照组[VAS评分:3.0(2.0,4.0)分比4.0(3.0,5.0)分,1.0(1.0,3.0)分比2.0(1.0,4.0)分;HIT-6评分:(47±4)分比(49±5)分,(42±5)分比(45±5)分](均P<0.05)。治疗2周后,观察组总有效率高于对照组[91.7%(55/60)比78.3%(47/60)](P<0.05),但2组不良反应发生率比较差异无统计学意义(P=0.543)。结论乙哌立松联合普瑞巴林治疗早期枕神经痛,可减轻患者的疼痛程度,改善疼痛对日常生活及工作的不良影响,疗效显著,且具有较高的安全性。

Objective To investigate the clinical effect of eperisone combined with pregabalin on the treatment of early occipital neuralgia.Methods Totally 120 patients with occipital neuralgia in Electric Power Teaching Hospital,Capital Medical University from October 2020 to June 2021 were selected.The patients were randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with routine treatment combined with pregabalin capsules,and the observation group was treated with eperisone hydrochloride tablets on the basis of the control group.Both groups were treated for 2 weeks.The scores of pain visual analogue scale(VAS)and headache impact test questionnaire-6(HIT-6)before treatment,1 and2 weeks after treatment,as well as the clinical effect and incidence of adverse reactions were compared between the two groups.Results After 1 and 2 weeks of treatment,the VAS and HIT-6 scores of the two groups were lower than those before treatment,those 2 weeks after treatment were lower than those 1 week after treatment,and those of the observation group were lower than those of the control group[VAS scores:3.0(2.0,4.0)vs 4.0(3.0,5.0),1.0(1.0,3.0)vs 2.0(1.0,4.0);HIT-6 scores:(47±4)vs(49±5),(42±5)vs(45±5)](all P<0.05).After 2 weeks of treatment,the total effective rate of the observation group was higher than that of the control group[91.7%(55/60)vs 78.3%(47/60)](P<0.05),but there was no significant difference in the incidence of adverse reactions between the two groups(P=0.543).Conclusions Eperisone combined with pregabalin in the treatment of early occipital neuralgia can reduce the degree of pain and improve the adverse effects of pain on daily life and work.It has significant curative effect and high safety.