沉默信息调节因子在高血压发病机制中的研究进展

Research progress of sirtuins in pathogenesis of hypertension

高血压是多种心血管疾病的主要危险因素。尽管许多研究都强调了高血压的多因素性,但是高血压的发病机制仍然有待探索。大量证据表明,表观遗传学在高血压发病中起着重要的作用[1],其中烟酰胺腺嘌呤二核苷酸(nicotimide adenosine dinucleo-tide,NAD^(+))依赖性酶家族介导的血管动态平衡和心血管疾病的表观遗传过程引起了研究者的广泛关注。分子水平上,NADPH氧化酶信号的激活、内源性抗氧化剂的抑制、DNA的甲基化、组蛋白的修饰和一氧化氮合酶(nitric oxide synthase,NOS)异构体蛋白表达的改变等共同参与了高血压的发病[2]。沉默信息调节因子(sirtuins/silent information regulators,SIRTs)作为NAD+依赖的脱乙酰酶,参与了高血压的形成与发展。本文将综述SIRTs家族不同成员在高血压发病中的作用。

The formation of hypertension is closely related to the activation of nicotinamide adenine dinucleo-tide phosphate(NADPH)oxidase signal.Sirtuins as a family of nicotinamide adenine dinucleotide(NAD+)dependent en-zymes,not only act on cardiomyocytes directly,but also participate in the regulation of vascular endothelial homeostasis,vascular stiffnessand remodeling.In addition,Sirtuins also affect blood pressure by changing with cell and vascular aging,participating in water and salt regulation,glucose and lipid metabolism,and even affect target organs such as the heart,most of which are positive regulation,which helps to reduce cardiovascular damage,a few are negative regulation,which promotes cardiovascular damage.This article reviews the different roles of sirtuins family members in the pathogenesis of hypertension.