大剂量生长抑素辅助内镜金属钛夹治疗胃溃疡消化道出血患者的效果

Effects of High Dose Somatostatin Assisted Endoscopic Metal Titanium Clip in the Treatment of Gastric Ulcer and Digestive Tract Hemorrhage

目的探讨大剂量生长抑素辅助内镜金属钛夹治疗胃溃疡消化道出血患者的临床效果。方法选取2019年3月至2020年6月确山县人民医院收治的86例胃溃疡消化道出血患者作为研究对象,根据治疗方法分为观察组和对照组,各43例。两组均接受常规干预,对照组接受常规剂量生长抑素辅助内镜金属钛夹治疗,观察组接受大剂量生长抑素辅助内镜金属钛夹治疗。比较两组临床总有效率、血常规指标[血小板分布宽度(PDW)、降钙素原(PCT)、血小板(PLT)]、炎症因子水平[肿瘤坏死因子-α(TNF-α)、表皮生长因子(EGF)、血管内皮生长因子(VEGF)]、不良反应总发生率。结果治疗后观察组临床总有效率(90.70%)与对照组(79.07%)比较,差异无统计学意义(P>0.05);观察组PDW、PCT均低于对照组,观察组PLT高于对照组(P<0.05);治疗后观察组EGF、VEGF高于对照组,TNF-α低于对照组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论大剂量生长抑素辅助内镜金属钛夹治疗能改善胃溃疡消化道出血患者的临床效果,减轻炎症反应,促进预后恢复。

Objective To explore the effects of high dose somatostatin assisted endoscopic metal titanium clips in the treatment of gastric ulcer and digestive tract bleeding.Methods A total of 86 patients with gastric ulcer and digestive tract bleeding in Queshan County People’s Hospital from March 2019 to June 2020 were selected,and they were divided into observation group and control group according to treating method,with 43 cases in each group.Both groups accepted conventional interventions.The control group accepted conventional dose of somatostatin assisted endoscopic metal titanium clamps,and the observation group accepted high dose somatostatin assisted endoscopic metal titanium clamps.The total clinical effectiveness,blood routine indexes[platelet distribution width(PDW),procalcitonin(PCT),platelets(PLT)],inflammatory factor levels[tumor necrosis factor-α(TNF-α),epidermal growth factor(EGF),vascular endothelial growth factor(VEGF)]and the total incidence of adverse reactions of the two groups were compared.Results After treatment,the total clinical effective rate(90.70%)of observation group was compared with that(79.07%)of control group,with no statistical difference(P>0.05).The levels of PDW and PCT of observation group were lower than those of control group,and the level of PLT of observation group was higher than that of control group(P<0.05).After treatment,the levels of EGF,VEGF of observation group were higher than those of control group,and the level of TNF-αof observation group was lower than that of control group(P<0.05).There was no statistical difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion High dose somatostatin assisted endoscopic metal titanium clip treatment can improve clinical efficacy of patients with gastric ulcer and digestive tract bleeding,reduce inflammation and promote prognosis recovery.