血清脂蛋白相关磷脂酶A_(2)及可溶性凝集素样氧化型低密度脂蛋白受体-1与急性心肌梗死患者Gensini积分的相关性

Correlation Between Serum Lipoprotein-Related Phospholipase A_(2), Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 and Gensini Score in Patients with Acute Myocardial Infarction

目的分析血清脂蛋白相关磷脂酶A_(2)(Lp-PLA_(2))及可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)与急性心肌梗死(AMI)患者Gensini积分的相关性。方法选取2020年3月至2021年7月焦作市人民医院收治的117例AMI患者作为研究组,另选同期126名健康体检者作为对照组。比较两组血清Lp-PLA_(2)、sLOX-1水平。比较不同病变冠状动脉分支及不同Gensini积分患者血清Lp-PLA_(2)、sLOX-1水平。探讨血清Lp-PLA_(2)、sLOX-1水平变化与Gensini积分的相关性。结果研究组血清Lp-PLA_(2)、sLOX-1水平高于对照组(P<0.05);随冠状动脉病变支数增加,Lp-PLA_(2)、sLOX-1水平持续升高,即单支病变患者血清Lp-PLA_(2)、sLOX-1水平低于双支及多支病变患者,双支病变患者血清Lp-PLA_(2)、sLOX-1水平低于多支病变患者(P<0.05);随Gensini积分升高,血清Lp-PLA_(2)、sLOX-1水平持续升高,即轻度患者血清Lp-PLA_(2)、sLOX-1水平低于中度及重度患者,中度患者血清Lp-PLA_(2)、sLOX-1水平低于重度(P<0.05);经Pearson分析显示,血清Lp-PLA_(2)(r=0.506,P<0.001)、sLOX-1(r=0.457,P<0.001)水平与Gensini积分呈正相关(P<0.05)。结论AMI患者体内血清Lp-PLA_(2)、sLOX-1水平呈高表达状态,且其水平随冠状动脉病变支数增加、Gensini积分升高而升高。

Objective To analyze the correlation between serum lipoprotein-related phospholipase A_(2)(Lp-PLA_(2)),soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1)and Gensini score in patients with acute myocardial infarction(AMI).Methods A total of 117 AMI patients who were admitted to Jiaozuo People’s Hospital from March 2020 to July 2021 were selected as study group,and 126 healthy persons during the same period were selected as control group.The levels of Lp-PLA_(2) and sLOX-1 were compared between the two groups.The levels of serum Lp-PLA_(2) and sLOX-1 in different coronary artery branches and different Gensini scores patients were compared,and the relationships between Lp-PLA_(2),sLOX-1 levels and Gensini scores were explored.Results The levels of Lp-PLA_(2) and sLOX-1 of study group were higher than those of control group(P<0.05).With the increase in the number of coronary artery lesions,the levels of Lp-PLA_(2) and sLOX-1 were increased,while the levels of Lp-PLA_(2) and sLOX-1 in patients with single-vessel disease were lower than those of patients with double-vessel and multivessel disease,and the levels of Lp-PLA_(2) and sLOX-1 in patients with double-vessel disease were lower than those of patients with multivessel disease(P<0.05).With the increase of Gensini score,the levels of Lp-PLA_(2) and sLOX-1 were increased,and the levels of Lp-PLA_(2) and sLOX-1 in mild patients were lower than those of moderate and severe patients,and the levels of Lp-PLA_(2) and sLOX-1 in moderate patients were lower than those of severe patients(P<0.05).Pearson analysis showed that the levels of Lp-PLA_(2)(r=0.506,P<0.001)and sLOX-1(r=0.457,P<0.001)were positively correlated with Gensini score(P<0.05).Conclusion Serum Lp-PLA_(2) and sLOX-1 levels are highly expressed in patients with AMI,and the levels are increased with the increase in the number of coronary artery disease and the rise in Gensini score.