TGF-β_(3)诱导牙源性干细胞修复牙槽骨缺损的研究进展

Research progress of TGF-β_(3) induced odontogenic stem cells to repair alveolar bone defects

牙槽骨是牙周组织和全身骨骼系统中代谢和改建最活跃的部分,具有较高的可塑性,它可以随着咀嚼压力而变动,也可以随着牙齿的移动而不断改建。牙槽骨缺损在临床上较为常见,对后续临床上治疗带来极大挑战,如何修复牙槽骨缺损是广大学者关注的热点。转化生长因子-β_(3)(TGF-β_(3))作为一种重要的骨生长调控因子,可被作为牙槽骨修复的生长因子。牙周膜干细胞(PDLSCs)和牙髓干细胞(DPSCs)是牙槽骨再生中最具有前景的牙源性间充质干细胞(MSCs)。已有多项实验证实了TGF-β_(3)通过Smads信号通路和p38MAPK信号通路这两条重要途径诱导牙源性干细胞成骨分化。本文结合近几年国内外文献,对TGF-β_(3)在诱导牙源性干细胞促进成骨分化的作用和其相关信号通路方面做一综述。

Alveolar bone is the most actively metabolized and remodeled part of the periodontal tissue and the whole skeletal system.It is highly plastic.It can change with the masticatory pressure and can also be constantly modified with the movement of teeth.Alveolar bone defects are common in clinical practice,which poses a great challenge to subsequent clinical treatment.How to repair alveolar bone defects is a hot spot for scholars.Transforming growth factor-β_(3)(TGF-β_(3)),an important bone growth regulator,can be used as a growth factor for alveolar bone repair.Periodontal ligament stem cells(PDLSCs)and dental pulp stem cells(DPSCs)are the most promising dental-derived mesenchymal stem cells(MSCs)for alveolar bone regeneration.A number of experiments have confirmed that TGF-β_(3) induces osteogenic differentiation of odontogenic stem cells through two important pathways,the Smads signaling pathway and the p38 MAPK signaling pathway.Based on the domestic and foreign literature in recent years,this article reviews the role of TGF-β_(3) in inducing odontogenic stem cells to promote osteogenic differentiation and related signal pathways.