ARDS中肺泡巨噬细胞自噬对肺损伤调节作用的研究进展

Research update on the regulatory effects of alveolar macrophage autophagy on lung injury in acute respiratory distress syndrome

失控的炎症反应是急性呼吸窘迫综合征(ARDS)发生发展的关键环节,而肺泡巨噬细胞自噬在ARDS的炎症反应中发挥重要的调节作用。本文对相关文献进行回顾,以深入了解在ARDS中肺泡巨噬细胞发生自噬的具体机制及肺泡巨噬细胞自噬对肺损伤的影响,为ARDS的治疗提供进一步的研究方向。

Uncontrolled inflammation is the fundament of the pathogenesis of acute respiratory distress syndrome(ARDS)and most researches show that autophagy of alveolar macrophages plays an important regulatory role in the inflammation of ARDS.This review focuses on the mechanism of alveolar macrophage autophagy in ARDS,states the influence of alveolar macrophage autophagy in lung injury,and provides research directions in the treatment of ARDS.