几丁质酶-3样蛋白-1在感染性疾病中的研究进展

Progress in study of chitinase-3-like protein-1 in infectious diseases

几丁质酶-3样蛋白-1(CHI3L1)在原核生物和真核生物中普遍存在,由多种细胞分泌,在哮喘、脓毒症、类风湿关节炎、冠状动脉病变等多种炎症疾病状态下可观察到CHI3L1的过表达。近20年,随着对CHI3L1在不同疾病中作用机制的不断探索及临床研究的逐渐深入,其重要性日益受到关注。本文就CHI3L1在各种急性感染中,特别是重症感染中的研究进展作一综述,以期对未来脓毒症的基础研究和临床研究有所启发。

Chitinase-3 like-protein-1(CHI3L1)is commonly expressed in prokaryote and eukaryote,and can be secreted by a multitude of cells.It has been observed that CHI3L1 is overexpressed in numerous inflammatory disease states including asthma,sepsis,rheumatoid arthritis,coronary artery disease and so on.In the last two decades,its has attracted more and more attention with continuous exploration of its mechanism in different diseases and gradual deepening of clinical researchs.This article reviewed the research progress of CHI3L1 in various acute infections,especially severe infections,in order to promote the basic and clinical research of sepsis in the future.