铜伴侣蛋白ATOX1在恶性肿瘤中作用机制的研究进展

Research progress on the mechanism of copper chaperone protein ATOX1 in malignant tumor

抗氧化剂1铜伴侣蛋白(antioxidant 1 copper chaperone,ATOX1)作为细胞内铜离子的运载体,是一种由68个氨基酸组成的高度保守水溶性蛋白,广泛分布于真核和原核生物体内。铜伴侣蛋白ATOX1参与铜的细胞摄取、转运与排出进而维持铜稳态。除此之外,ATOX1还具有转录因子和抗氧化的功能。近年来大量的研究发现ATOX1可以通过多种途径影响肿瘤的发生、发展、增殖与迁移等过程,这为肿瘤形成机制的研究提供了一个新的方向。在本篇综述中,我们探究了ATOX1在肿瘤的迁移、转录、细胞周期以及癌症相关信号通路中的作用机制,并总结了其在临床肿瘤治疗方面的研究进展,旨在为临床肿瘤的防治提供一个崭新的治疗靶点。

Antioxidant 1 copper chaperone(ATOX1)is a highly conserved water-soluble protein composed of 68 amino acids,which is widely distributed in eukaryotes and prokaryotes.The copper chaperone protein ATOX1 is involved in the uptake,transport and excretion of copper,thus maintaining copper homeostasis.In addition,ATOX1 also has the function of transcription factor and antioxidant.In recent years,a large number of studies have found that ATOX1 can affect the occurrence,development,proliferation and migration of tumors through a variety of ways,which provides a new direction for the study of tumor formation mechanism.In this review,we explored the mechanisms of ATOX1 in tumor migration,transcription,cell cycle and cancer-related signaling pathways,and summarized its research progress in clinical tumor treatment,aiming to provide a new therapeutic target for clinical tumor prevention and treatment.