摘要
Neurodegenerative disorders are characterized by disruptions to neuronal function and circuitry,leading to a variety of clinical syndromes depending on the affected neuroanatomic regions(Geula,1998).Many proteinopathies implicated in neurodegenerative diseases are characterized by the pathologic accumulation of proteins into inclusions that are initially deposited in specific areas of the brain and spread widely with disease progression.
基金
supported by grants from the National Institute of Neurological Disorders and Stroke,No.NS085770
National Institute on Deafness and Other Communication Disorders No.DC008552
National Institute on Aging,No.AG062566 and AG065463
an institutional training grant from the National Institute of Neurological Disorders and Stroke,No.NS047987
an Alzheimer’s Disease Center Grant from the National Institute on Aging,No.AG013854。
