nectin-3蛋白在胰腺癌中的研究进展

Research progress on the relationship between nectin-3 and pancreatic cancer

Nectins是近年来发现的一类不依赖Ca2+的免疫球蛋白超家族细胞黏附分子。Nectins蛋白家族共有4个成员:nectin-1、nectin-2、nectin-3及nectin-4。众多研究证实Nectins家族的各个成员与多种肿瘤的发生、发展和侵袭有关。有研究发现,胰腺癌中nectin-3弥漫性表达与预后良好相关;nectin-3低表达与胰腺神经内分泌肿瘤侵袭性增强有关。nectin-3对判断胰腺癌的恶性程度、预测肿瘤侵袭转移和评估其预后是一个有价值的生物学指标。但nectin-3在胰腺癌中促进侵袭转移的内在机制目前还不清楚,仍需要深入研究。

Nectins are a family of Ca2+-independent immunoglobulin superfamily cell adhesion molecules,consisting of four members,nectin-1,nectin-2,nectin-3 and nectin-4.Numerous studies have shown that Nectins are involved in the occurrence,development,invasion and metastasis of various tumors.Studies have found that diffuse nectin-3 expression in pancreatic cancer is associated with a good prognosis,and low expression of nectin-3 is associated with increased invasion of pancreatic neuroendocrine tumors.Nectin-3 is a valuable biological indicator for determining the malignancy of pancreatic cancer,predicting tumor invasion and metastasis,and evaluating its prognosis.However,the mechanism of nectin-3 promoting invasion and metastasis in pancreatic cancer is still unclear,and further research is still needed.