摘要
发展了一种以价格便宜的三氟甲磺酸镍为催化剂,以环二芳基高价碘为原料制备2,7-二芳基苯并噁唑的新方法。在考察了催化剂、碱、溶剂等一系列反应条件后,我们建立了最佳的反应条件。基于该反应条件,结构多样化的2,7-二芳基苯并噁唑类产物都可以顺利生成,产率在66%~89%之间,经过^(1)H NMR、^(13)C NMR确证了所得化合物的结构。该反应表现出原料易得、操作简便、条件温和、对官能团耐受性好等优势,对苯并噁唑衍生物的合成具有重要的意义。
A new access to 2,7-diaryl benzoxazole scaffolds from cyclic diaryl iodoniums via cheap nickel catalysts was developed.The optimized reaction conditions were developed when factors including catalyst,base and solvent were screened.A serials of structurally diversified 2,7-diaryl benzoxazole derivatives were constructed and characterized by ^(1)H NMR、^(13)C NMR.The conversion features readily available start materials,simple operation,mild conditions,and high compatible of diversified substituents.It is of great importance for constructing benzoxazole derivatives.
作者
李杭霓
朱大潜
Li Hangni;Zhu Daqian(School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China)
出处
《广东化工》
CAS
2021年第21期10-11,9,共3页
Guangdong Chemical Industry
基金
2018年度广东省自然科学基金“基于不对称环芳基高价碘化合物区域选择性及新型串联反应的研究”(2018A030310240)
广东药科大学“高层次人才”科研启动经费(51340332,51340336)。
关键词
环二芳基高价碘
苯并噁唑
镍催化
C-O键形成
分子内反应
cyclic diaryliodoniums
benzoxazole
nickel catalysis
C-O bond formation
intramolecular reaction