盐酸普拉克索合成路线图解

Graphical Synthetic Routes of Pramipexole Dihydrochloride

盐酸普拉克索是由德国勃林殷格翰公司开发的多巴胺D2/D3受体完全激动剂。单独用于治疗早期PD患者,与左旋多巴联用治疗晚期PD患者,能显著改善患者运动症状,耐受性及安全性良好,同时具有中枢神经元的保护作用和改善PD患者抑郁症状的作用,已成为治疗PD的一线药物。对其研究具有重要意义。本文对盐酸普拉克索的合成路线进行了总结,利用图解的方式对盐酸普拉克索合成路线进行了综述和评价。

Pramipexole,which was developed by Boehringer Ingelheim company,is a complete agonist of the D2/D3 dopamine receptors.Pramipexole is an effective monotherapy in treating early PD and an adjunctive therapy with levodopa in advanced PD.It could significantly improve motor symptoms of patients with good tolerability and safety.Also it was considered to possess neuroprotective properties and antidepressant activity,it has become the first line drug in treatment of PD.The study for its synthesis has important significance.In this article,we conclude its synthetic route,graphic method was used to review and evaluate its synthetic process.