北京地区高血压患者用药依从性及影响因素调查与研究

Risk factors investigation on medication adherence of Chinese hypertension patients in Beijing

目的:调查北京地区高血压患者药物治疗依从性及达标率现状,分析依从性的主要影响因素和药师提供药学服务后患者依从性的改善情况,以期为后续制定社区药学服务干预措施提供数据支持。方法:设计依从性及影响因素调查问卷,药师通过面对面访谈的形式开展前瞻性调研并提供药学服务,跟踪随访3个月,比较依从性变化。结果:共调研高血压患者1382人,药学服务前后依从性差的患者例数为447(32.34%)和356(25.76%),两者比较有统计学差异(P<0.05);多因素Logistics回归显示年龄、吸烟、饮酒、自行经验购药、体育锻炼和生活方式是依从性的独立影响因素(P<0.05)。结论:我国高血压患者的药物治疗依从性现状仍然不太理想,药学服务能显著提高患者的用药依从性。针对依从性危险因素,今后药学干预措施应侧重于高血压用药知识宣教、加强体育锻炼、戒烟宣传及健康生活方式指导。

OBJECTIVE To explore the prevalence of medication adherence and standard rate of Chinese hypertension patients in Beijing,analyze the major risk factors of medication adherence and the improvement after pharmaceutical care and provide data supports for follow-up development of community pharmaceutical care intervention measures.METHODS Questionnaires were designed for medication adherence and risk factors.Pharmacists conducted a prospective survey and provided pharmaceutical care through face-to-face interviews.Follow-up was conducted for 3 months to compare the changes in adherence.RESULTS A total of 1382 hypertension patients were surveyed.The number of patients with poor adherence before and after pharmaceutical care was 447(32.34%)and 356(25.76%)with statistical difference between them(P<0.05).Multivariate Logistic regression showed that age,smoking,alcohol consumption,self-experience drug purchase,physical exercise and lifestyle were independent risk factors of adherence(P<0.05).CONCLUSION Pharmaceutical care can significantly improve the medication adherence of hypertension patients.Future pharmaceutical intervention measures should focus upon education of hypertension medication knowledge,strengthening physical exercise,smoking cessation publicity and healthy lifestyle education according to risk factors.