GDF10在中枢神经系统损伤后的修复作用

The Repairing Effect of GDF10 after Central Nervous System Injury

生长分化因子10(growth differentiation factor 10,GDF10)是转化生长因子β(transforming growth factor beta,TGFβ)超家族的一员。GDF10在正常组织中表达量很低或不表达,而在中枢神经系统损伤后却显著升高,这提示GDF10可能作为神经系统疾病的治疗靶点。近期研究表明,GDF10在大脑皮层中风周区具有促进神经元轴突出芽的作用。此外,GDF10在脊髓损伤后高表达并具有神经保护作用。因此该文将对GDF10的表达调控、细胞信号通路的研究进展进行总结,尤其是GDF10在中枢神经系统损伤后的作用,以探讨GDF10的生物活性及其在药物开发、应用基础研究中的价值。

GDF10(growth differentiation factor 10)is a superfamily member of TGFβ(transforming growth factor beta).GDF10 in normal tissue is rare or no expression.However,during the injury in the central nervous system,it has a significant rise.It may prompt for GDF10 as therapeutic targets.Recent studies show that GDF10 in the brain cortex area of peri-infarct can promote neural axonal sprouting after ischemia stroke.Moreover,GDF10 highly express after SCI(spinal cord injury)and protect neural function.Therefore,this article will summarize the research progress of GDF10 expression regulation and cell signaling pathways,especially the role of GDF10 after central nervous system injury,in order to explore the biological activity of GDF10 and its value in drug development and application basic research.