1990~2019年中国痤疮疾病负担变化的分析

Analysis of the change in disease burden of acne vulgaris in China from 1990 to 2019

目的分析1990~2019年中国痤疮疾病负担的变化趋势,为痤疮的防控提供依据。方法利用全球疾病负担数据库,检索中国痤疮的发/患病数、年龄标准化发/患病率、DALYs(伤残调整寿命年)/DALY率及中国和全球的社会人口学指数(SDI值),分析中国1990~2019年痤疮的流行趋势及年龄、时期、出生队列趋势,以及痤疮发病率与SDI之间的关系。结果2019年,中国痤疮患病率及发病率均高于全球平均水平,患病人数较1990年稍有增长(3.91%),发病率、患病率及DALY率均持续上升。中国痤疮发病率年龄趋势以10~14岁为界,患病率以15~19岁为界,均呈现出先升高后降低的趋势。女性比率均高于男性,具有明显的性别差异。年龄-时期-队列模型分析显示,1990~2019我国痤疮发病率的净漂移值、年龄效应、时期效应、队列效应均存在统计学差异。随着SDI值的增加,痤疮的发病率呈线性上升趋势。结论1990~2019年间,中国痤疮疾病负担呈上升趋势。

Objective To evaluate the disease burden of acne vulgaris in China from 1990 to 2019 and to provide references for the prevention and control of acne vulgaris in China.Methods The quantity of incidences/illnesses,agestandardized incidence/prevalence rates,disability-adjusted life years(DALYs),and DALY rate of acne vulgaris in China from 1990 to 2019 which were derived from the Global Burden of Disease(GBD)2019 were evaluated.The epidemiological trends,age-birth-cohort trends,and the relationship between the incidence and sociodemographic index(SDI)were also analyzed.Results In 2019,the prevalence and incidence of acne vulgaris in China were higher than the global average.The quantity of patients was slightly higher in 2019 than that in 1990(3.91%),and the prevalence,incidence,and DALY rate showed a continuous growth trend.The incidence of acne vulgaris peaked at 10 to 14 years old.Acne vulgaris mostly affected young males,and its prevalence peaked at approximately 15 to 19 years old.With these two age groups as the boundary,there was a trend of the prevalence of acne vulgaris increasing initially and then decreasing.Obvious gender differences existed for acne vulgaris diagnoses,and most of the above indicators were shown at a higher level in females than in males.The age period cohort analysis showed that the incidence rate of acne vulgaris in China from 1990 to 2019 was significantly different from the net drift,age effect,period effect and cohort effect.As the SDI value increased,the incidence of acne vulgaris showed a linear growth trend.Conclusions From 1990 to 2019,the burden of acne disease in China increases significantly.