长期服用丹参人参提取物对高强度力竭性运动人群的冠状动脉血流速度的影响

Effect of long-term use of Danshen on the coronary flow velocity of high intensity exhaustive exercise crowd

目的研究人体长期摄取丹参人参提取物对降低高强度运动后动脉血流速度的影响。方法将纳入受试者随机分为2组:35例受试者为对照组、35例受试者试验组。在进行力竭运动前,对照组受试者摄入对安慰剂,试验组摄入丹参人参提取物(人参皂苷Rg3人参皂苷Rh2胶囊,每次500 mg;冠心丹参胶囊,每次600 mg,均2次/天),连续15 d。在受试者摄入后48 h内,进行力竭运动。比较2组受试者在运动前至运动后72 h颈动脉收缩压(CSBP)、颈动脉平均收缩压(CMBP)、反射波压力(BP)、主动脉阻抗(AI)以及心内膜下心肌活力率(SEVR)。观察2组的药物不良反应发生率。结果治疗后,对照组和试验组的临床治疗有效率分别为0和51.42%,组间比较差异有统计学意义(P<0.05)。在力竭运动后72 h,对照组和试验组的CSBP分别为(106.87±4.41),(94.35±2.29)mmHg;这2组的CMBP分别为(80.34±8.82),(76.09±5.52)mmHg;这2组的BP分别为(15.87±1.88),(22.33±2.02)mmHg;这2组的AI分别为(151.34±19.33),(208.84±22.98)dyne·s^(-1)·cm^(-3);这2组的SEVR分别为(181.12±20.23)%,(258.54±18.87)%。上述指标组间比较,差异组间比较差异均有统计学意义(均P<0.05)。对照组与试验组的药物不良反应发生率分别为8.57%,2.85%,组间比较差异无统计学意义(P>0.05)。结论连续摄入丹参人参提取物并不能保护肌肉减少肌肉损伤,但可以加速冠状动脉血流指标恢复。

Objective To study the effect of long-term intake of salvia and ginseng extracts on the reduction of arterial blood flow velocity after high-intensity exercise.Methods The included subjects were randomly divided into two groups:control group and treatment group,with 35 cases in each group.Before exhausting exercise,the control group took placebo,and the treatment group took Danshen ginseng extract(ginsenoside Rg3 ginsenoside Rh2 capsules,500 mg each time;Guanxin Danshen capsules,600 mg each time,Both times/day)for 15 consecutive days.Exhaustive exercise was performed within 48 h after the subjects ingested.The carotid systolic blood purification(CSBP),carotid mean blood purification(CMBP),backward pressure(BP),aortic impedance(AI)and subendocardial viability ratio(SEVR)were compared between the two groups of subjects from before exercise to 72 h after exercise.The incidence of adverse drugs reaction in two groups was investigated.Results After treatment,the clinical treatment effective rates of the control group and treatment group were 0 and 51.42%,respectively,and the difference was significant(P<0.05).Seventy-two hours after exhaustive exercise,the CSBP of the control group and treatment group were(106.87±4.41),(94.35±2.29)mm Hg;CMBP of the two groups were(80.34±8.82),(76.09±5.52)mm Hg;BP of the two groups were(15.87±1.88),(22.33±2.02)mm Hg;AI of the two groups were(151.34±19.33),(208.84±22.98)dyne·s-1·cm-3;SEVR of the two groups were(181.12±20.23)%,(258.54±18.87)%.Comparison between treatment group and control group,the difference of the factors were significant(all P<0.05).The incidence of adverse drug reactions in control group and treatment group were 8.57%and 2.85%,respectively,and the the difference was not statistically significant(P>0.05).Conclusion Continuous intake of Danshen and ginseng extract can not protect muscles and reduce muscle damage,but can accelerate the recovery of coronary blood flow indicators.