摘要
微针是一种新型的给药系统,能穿透皮肤角质层,形成微孔通道,促进药物的渗透,在疫苗递送中有重要作用。本文从微针透皮的原理,以不同类型微针在疫苗递送中的作用等方面系统地阐述了微针透皮技术在疫苗接种中的应用,并展望了微针疫苗未来的发展方向。
Microneedles can penetrate the cuticle of the skin to form microporous channels and promote drug penetration.It is a new drug delivery system and plays an important role in vaccine delivery.In this paper,the application of microneedles transdermal technology in vaccine inoculation was systematically elaborated from the aspects of the principle of microneedle transdermal,the role of different types of microneedles in vaccine delivery,and the future development direction of microneedles vaccine was prospected.
作者
翟优
王丽娜
金华倩
黄玉洁
金烨成
ZHAI You;WANG Li-na;JIN Hua-qian;HUANG Yu-jie;JIN Ye-cheng(Research Center of Clinical Pharmacy,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China;Zhejiang Provincial Key Laboratory far Drug Evaluation and Clinical Research,Hangzhou 310003,Zhejiang Province,China;Department of Pharmacy,The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,Zhejiang Province,China;a.Biomedical Research Centre,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,Zhejiang Province,China;Department of Science and Education,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,Zhejiang Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2021年第21期2969-2973,共5页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81801644)。
关键词
微针
透皮给药
疫苗
包衣微针
空心微针
溶解微针
microneedle
transdermal delivery
vaccine
coated microneedles
hollow microneedles
dissolving microneedles
