银杏叶提取物对精神分裂症患者阴性症状认知功能及IL-1βIL-6的影响

The effects of ginkgo biloba extract on cognitive function and oxidative stress in patients mth schizophrenia

目的分析精神分裂症患者银杏叶提取物治疗前后阴性症状、认知功能和外周血中IL-1β、IL-6的变化方法选取2018年1月至2019年1月精神分裂症患者120例,分为观察组和对照组各60例,分别于治疗前后应用阳性与阴性症状量表(PANSS)评定患者的临床症状严重程度,重复性成套神经心理状态测验(RBANS)评定认知功能,同时检测外周血中IL-1β、IL-6水平,结果观察组IL-1β差值、IL-6差值、IMNSS总分及阴性症状分差值低于对照组,RBANS总分及各因子分差值高于对照组(P<0.05);治疗后观察组IL-1β、IL-6含量低于治疗前,PANSS总分及各因子分、RBANS总分以及各因子分高于治疗前(P<0.001);观察组IL-1β差值和IL-6差值与PANSS总分差值呈正相关,与RBANS总分差值及即刻记忆、言语功能、注意功能以及延时记忆因子差值呈负相关(r=-0.612〜0.560,P<0.01);IL-1β差值和IL-6差值可以解释PANSS总分差值变异的34.70%,IL-6差值可分别解释RI3ANS总分、即刻记忆、视觉广度、言语功能、注意力、延时记忆变异的34.80%,34.40%,21.80%,30.90%,36.40%,38.60%(P<0.05)结论银杏叶提取物可改善精神分裂症患者的阴性症状、认知功能,可能与改善炎症因子IL-1β、IL-6水平有关。

Objective To analyze the difference of negative symptoms,cognitive function and IL-1β,IL-6 in peripheral blood of patients with schizophrenia before and after treatment with ginkgo biloba extract,and to further analyze the relationship between them.Methods According to the hospitalization number,60 patients with schizophrenia in Kangning Hospital Affiliated to Wenzhou Medical University during January 2018 to January 2019 who met the admission criteria and exclusion criteria were randomly selected as the study group and the control group,respectively.After entering the group,the mental symptoms and the severity of the disease were evaluated with positive and negative syndrome scale(PANSS),the cognitive function was evaluated by reperidve neuropsychological state test(RBANS).At the same time,the contents of IL-1βand IL-6 in peripheral blood were detected before and after treatment.The collected data was analyzed by SPSS20.0.Results①The IL-1βdifference,IL-6 difference,PANSS total score difference,negative symptoms factor score difference were significantly lower than those in the control group.RBANS total score difference and factor score difference in the study group were significantly higher than those in the control group(P<0.001).②After treatment with ginkgo biloba extract,the contents of IL-1β,IL-6,the total score of PANSS and the scores of each factor were lower than those before treatment,and the total score of RBANS and the scores of each factor were significantly higher than those before treatment(P<0.001).③During the treatment,the difference of IL-1βand IL-6 were positively correlated with the difference total score of PANSS,were negative correlated with the difference of total score of RBANS and the difference of memory,speech function,attention function and delayed memory factor(r=-0.612~0.560,P<0.01).④The change level of IL-1βand IL-6 could explain 34.7%of the variation of PANSS total score,and IL-6 difference could explain 34.80%,34.40%,21.80%,30.90%,36.40%,38.60%of the variation of RBANS total score,instant memory,visual span,speech function,attention,and delay memory respectively.Conclusion Ginkgo biloba extract can improve negative symptoms and cognitive Rinction of patients with schizophrenia,which may be related to improving the levels of inflammatory cytokines IL-1βand IL-6.