高尔基体蛋白73和FIB4指数对非酒精性脂肪肝病肝硬化的诊断价值

目的探讨血清高尔基体蛋白73(GP73)和FII34指数对非酒精性脂肪肝病(NAFLD)肝硬化的诊断价值方法分别测定46例NAFLD肝硬化患者和122例NAFLD非肝硬化患者及200例健康体检者的血清GP73、FIB4指数、BMI、WBC、PLT、Hgb、生化指标和肝纤维化指标的水平;分析GP73和FIB4指数与其他指标的相关性;Logistic多因素回归分析NAFLD肝硬化的风险因素;ROC曲线分析GP73、FII34指数及其他危险因素对NAFLD肝硬化的预测效能结果NAFLD肝硬化组C;P73水平和FIB4指数高于NAFLD非肝硬化组及健康对照组(P<0.05).CP73水平与FIB4指数呈高度相关(r=0.892,P<0.001)Logistic回归分析显示,GP73和FIB4指数为NAFLD肝硬化发生的独立危险因素[GP73:(OR:2.982,95%CI:2450〜4.705);FIB4指数:(OR 2.024,95%CI 1.892-2.247),P<0.001]血清GP73和F1B4指数的KOC曲线下面积分别为0.894和0.882,高于其余各指标。当GP73水平≥136.2(ng/mL)时,NAFLD的患病率达83.32%;当HB4指数≥1.5时,NAFLD的患病率为76.47%结论血清GP73水平和FII34指数是NAFLD肝硬化发生的独立危险因素,这2者指标对NAFLD肝硬化早期诊断具有较高的预测价值。

Objective To investigate the diagnosis value of semm Golgi protein 73 and FIB4 index in non-alcoholic fatty liver disease cirrhosis.Methods GP73,FIB4,BMI,WBC,PLT,Hgb,Biochemical indicators and hepatic fibrosis indicators levels of 46 patients with cirrhosis of NAFLD,122 p«itients without cirrhosis of NAFLD and 200 healthy individuals were measured,respecrively.The correbtions were analyzed between GP73 and FII34 or Other indicators,the risk factors of cirrhosis of NAFLD and predicting power of GP73 and FIB4 were evaluated by logistic regression analysis and ROC curve,respectively.Results GP73 and FIB4 levels were higher in cirrhosis of NAFLD group than in without cirrhosis of NAFLD group and healthy control group(P<0.05).The GP73 level was highly correlated with FIB4 levels(r=0.892,P<0.0001).Regression analysis showed that GP73 and FIB4 were independent risk fiictors for cirrhosis of NAFLD.[GP73:(OR:2.982,95%CI:2450-4.705;FIB4:2.024,95%CI:1.892-2.247),P<0.001].The area under the ROC curve of GP73 and FIB4 were,0.894 and 0.882,respectively,and were higher than the others.When the level of serum GP73≥136.2(ng/ml),the prevalence rate of NAFLD can be«is high as 83.32%;when the level of FIB4 index≥1.5,the prevalence rate of NAFLD is 76.47%.Conclusion Serum GP73 and FIB4 are independent risk factors of cirrhosis in patients with NAFLD and have high predictive value for early diagnosis ot cirrhosis of NAFLD.