肠道菌群与动脉粥样硬化关联性及中医药干预作用的研究进展

Research Progress on the Relationship Between Intestinal Flora and Atherosclerosis and the Intervention Effect of TCM

动脉粥样硬化(AS)是一个慢性炎症过程,也是心血管疾病等多种疾病发生的重要病理基础。肠道菌群失调可诱发和加重炎症反应,加速代谢紊乱和免疫功能下降,影响动脉粥样硬化相关疾病的进展和转归。目前肠道菌群与动脉粥样硬化的相关研究逐渐成为热点,随着现代医学对二者联系认识的加深,相关中医药对AS的干预也成为临床治疗的重要手段。文章回顾和梳理了肠道菌群与动脉粥样硬化发生、发展及相关机制,并对中医药方法通过干预调节肠道菌群而发挥抗AS的相关作用进行综述,以期为中医防治AS及相关疾病的研究提供新思路。

Athero-sclerosis(AS)is a chronic inflammatory process and an important pathological basis for the occurrence of various diseases such as cardiovascular disease.Intestinal microflora disorders can induce and aggravate inflammatory reactions,accelerate metabolic disorders and decline in immune function,and affect the progression and outcome of atherosclerosis-related diseases.At present,the research on intestinal flora and atherosclerosis has gradually become a hot spot.With the deepening of modern medicine's understanding of the relationship between the two,the intervention of related traditional Chinese medicine on AS has also become an important means of clinical treatment.This article reviews and combs the occurrence,development and related mechanisms of intestinal flora and atherosclerosis,and summarizes the anti-AS effects of traditional Chinese medicine methods through intervention to regulate intestinal flora in order to prevent and treat AS and related Disease research provides new ideas.