摘要
Alzheimer’s disease(AD)is a neurodegenerative disease that currently cannot be cured by any drug or intervention,due to its complicated pathogenesis.Current animal and cellular models of AD are unable to meet research needs for AD.However,recent three-dimensional(3D)cerebral organoid models derived from human stem cells have provided a new tool to study molecular mechanisms and pharmaceutical developments of AD.In this review,we discuss the advantages and key limitations of the AD cerebral organoid system in comparison to the commonly used AD models,and propose possible solutions,in order to improve their application in AD research.Ethical concerns associated with human cerebral organoids are also discussed.We also summarize future directions of studies that will improve the cerebral organoid system to better model the pathological events observed in AD brains.
基金
This review was supported in part by grants from the Key R&D Program of Ningxia(2018BFG02005 to J.L.,2021BEG03100 to Y.Y.)
the National Natural Science Foundation of China(82060792 and 81660645 to Y.Y.,81660673 to J.L.)
the Natural Science Foundation of Ningxia(2020AAC03133 to Y.Y.,2021AAC03143 to J.L.)
the Fourth Batch of Ningxia Youth Talents Supporting Program(TJGC2019091 to J.L.,TJGC2019100 to Y.Y.)
the National College Students Innovation and Entrepreneurship Training Program(S202010752039 to F-C.B.).
