摘要
Advancing age is a major risk factor for Alzheimer’s disease(AD).This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging.Correlative and modeling studies can inform this question,but without a frm grasp of what drives aging and AD it is difcult to defnitively resolve this quandary.This review speculates over the relevance of a particular hallmark of aging,mitochondrial function,to AD,and further provides background information that is pertinent to and provides perspective on this speculation.
基金
The authors are supported by P30AG035982
HMW is additionally supported by R00AG056600.