住院精神分裂症患者生活质量调查及与认知功能和社会支持的关系分析

Investigation on the Quality of Life in Patients with Schizophrenia and Its Relationship with Cognitive Function and Social Support

目的:调查住院精神分裂症患者生活质量情况,并分析生活质量与认知功能和社会支持的关系。方法:本次研究为回顾性分析,将2019年1月-2020年10月期间于我院住院的精神分裂症患者225例纳为病例组。通过宣传招募健康志愿者200例作为对照组。对比两组生活质量、社会支持评分和认知功能,住院精神分裂症患者生活质量的影响因素采用单因素和多因素Logistic回归分析。住院精神分裂症患者生活质量与认知功能和社会支持的关系采用Pearson相关性分析。结果:病例组的健康状况调查问卷(SF-36)评分、社会支持评定量表(SSRS)评分均低于对照组(P<0.05)。威斯康星卡片分类测验(WCST)结果显示,病例组的错误应答数高于对照组,正确应答数低于对照组(P<0.05),Stroop色词测验结果显示,病例数正确数低于对照组,错误数高于对照组(P<0.05)。Pearson相关性分析结果显示,住院精神分裂症患者SF-36评分与SSRS评分呈正相关(P<0.05)。住院精神分裂症患者生活质量与文化程度、性别、年龄、病程、药物治疗、住院时间情况有关(P<0.05)。多因素Logistic回归分析结果显示,年龄、病程、住院时间、药物治疗情况为影响住院精神分裂症患者生活质量的危险因素(P<0.05)。结论:住院精神分裂症患者的生活质量低于健康人群,影响其生活质量的因素主要包括社会支持以及患者的年龄、病程、住院时间、药物治疗情况。

Objective:To investigate the quality of life in patients with schizophrenia,and analyze the relationship between quality of life and cognitive function and social support.Methods:225 schizophrenic patients who were admitted to our hospital from January 2019 to October 2020 were included in the case group.200 healthy volunteers were recruited as control group.The quality of life,social support score and cognitive function of the two groups were compared.The influencing factors of the quality of life of hospitalized patients with schizophrenia were analyzed by univariate and multivariate logistic regression analysis.Pearson correlation analysis was used to analyze the relationship between quality of life and cognitive function and social support in hospitalized patients with schizophrenia.Results:The scores of health status questionnaire(SF-36)and social support rating scale(SSRS)in the case group were lower than those in the control group(P<0.05).Wisconsin Card Sorting Test(WCST)showed that the number of wrong answers in the case group was higher than that in the control group,and the number of correct answers was lower than that in the control group(P<0.05).Stroop Color word test showed that the number of positive answers in the case group was lower than that in the control group,and the number of errors was higher than that in the control group(P<0.05).Pearson correlation analysis showed that SF-36 score was positively correlated with SSRS score(P<0.05).The quality of life of patients with schizophrenia was related to education level,gender,age,course of disease,drug treatment and length of stay(P<0.05).Multivariate logistic regression analysis showed that,age,course of disease,length of hospital stay and drug treatment were the risk factors affecting the quality of life of inpatients with schizophrenia(P<0.05).Conclusion:The quality of life of hospitalized schizophrenic patients is lower than that of healthy people.The main factors affecting the quality of life include social support,age,course of disease,length of hospital stay and drug treatment.