骨康胶囊联合氨基葡萄糖治疗胫骨平台骨折的临床研究

Clinical study of Gukang Capsules combined with glucosamine in treatment of tibial plateau fracture

目的探讨骨康胶囊联合氨基葡萄糖胶囊治疗胫骨平台骨折的临床疗效。方法选取2019年2月—2021年1月在广西北海市第二人民医院就诊的80例胫骨平台骨折患者作为研究对象,按照治疗方法将80例患者分为对照组和观察组,各包括40例。对照组口服氨基葡萄糖胶囊,0.75 g/次,2次/d。观察组在对照组的基础上口服骨康胶囊,1.6 g/次,3次/d。两组连续治疗6个月。观察两组的临床疗效、骨折愈合时间和完全负重时间,同时比较两组治疗前后的血清中β-胶原降解产物(β-CTX)、骨钙素(BGP)、骨特异性碱性磷酸酶(BALP)的水平,以及视觉模拟评分法(VAS)、Lysholm功能量表评分情况。结果治疗后,观察组的总有效率为92.50%,对照组为75.00%,组间比较有明显差异(P<0.05)。治疗后,两组β-CTX、BGP、BALP水平均显著升高(P<0.05);治疗后,观察组的β-CTX、BGP、BALP水平显著高于对照组,差异有统计学意义(P<0.05)。治疗后,两组VAS评分显著降低,Lysholm评分明显升高(P<0.05);且治疗后,观察组VAS评分显著低于对照组,Lysholm评分高于对照组(P<0.05)。治疗后,观察组的骨折愈合时间、完全负重时间均短于对照组,差异有统计学意义(P<0.05)。结论骨康胶囊联合氨基葡萄糖胶囊可促进胫骨平台骨折术后的骨折愈合,改善膝关节功能,减轻疼痛程度,可能与调节骨代谢指标有关,具有良好临床意义。

Objective To investigate the clinical effect of Gukang Capsules combined with Glucosamine Capsules in treatment of tibial plateau fracture.Methods Eighty patients with tibial plateau fracture treated in the Guangxi Beihai Second People’s Hospital from February 2019 to January 2021 were selected as the research subjects.According to the treatment methods,the 80 patients were divided into control group and observation group,including 40 patients in each group.Patients in the control group were po administered with Glucosamine Capsules,0.75 g/time,twice daily.Patients in the observation group were po administered with Gukang Capsules on the basis of control group,1.6 g/time,three times daily.The two groups were treated for 6 months.Clinical efficacy,fracture healing time,and full weight bearing time of two groups were observed.Serum levels ofβ-CTX,BGP,and BALP,the scores of VAS and Lysholm functional scale were compared before and after treatment between two groups.After treatment,the total effective rate of the observation group was 92.50%,and that of the control group was 75.00%,there was a significant difference between groups(P<0.05).After treatment,the levels ofβ-CTX,BGP and BALP in two groups were significantly increased(P<0.05).After treatment,the levels ofβ-CTX,BGP,and BALP in the observation group were significantly higher than those in the control group,with statistical significance(P<0.05).After treatment,VAS score in two groups was significantly decreased,while Lysholm score was significantly increased(P<0.05).After treatment,the VAS score in the observation group was significantly lower than that in the control group,and the Lysholm score was higher than that in the control group(P<0.05).After treatment,the fracture healing time and full weight bearing time in the observation group were shorter than those in the control group,with statistical significance(P<0.05).Conclusion Gukang Capsules combined with Glucosamine Capsules can promote postoperative fracture healing of tibial plateau fracture,improve knee function and relieve pain,which may be related to the regulation of bone metabolism indexes,and has good clinical significance.