丹参注射液联合生长抑素治疗急性胰腺炎的疗效及其对血清CRP、MCP-1、NLR的影响

Effect of Danshen Injection combined with somatostatin in treatment of acute pancreatitis and its influence on serum CRP,MCP-1 and NLR

目的探讨丹参注射液联合生长抑素治疗急性胰腺炎的临床疗效。方法选取2018年1月—2021年2月阜阳市人民医院收治的94例急性胰腺炎患者作为研究对象,根据治疗方法患者分为对照组和观察组,每组各47例。对照组静脉滴注注射用生长抑素,0.25 mg加入500 mL的生理盐水充分稀释,以250μg/h速度进行滴注,1次/d。观察组在对照组基础上静脉滴注丹参注射液,20 mL加入250 mL的生理盐水充分稀释后静脉滴注,1次/d。两组均连续治疗7 d。观察两组患者的临床疗效、症状和体征恢复时间,同时比较两组治疗前后的血清C反应蛋白(CRP)、人巨噬细胞趋化蛋白-1(MCP-1)、中性粒细胞/淋巴细胞比值(NLR)和淀粉酶的水平及血液流变学指标水平。结果治疗后,观察组患者总有效率为95.74%,明显高于对照组的82.98%,差异有统计学意义(P<0.05)。治疗后,观察组淀粉酶、电解质恢复时间、腹痛消失时间、腹胀消失时间均较对照组短,差异有统计学意义(P<0.05)。治疗后,两组的CRP、MCP-1、NLR、血清淀粉酶水平均显著降低(P<0.05);治疗后,观察组的CRP、MCP-1、NLR、淀粉酶水平显著低于对照组(P<0.05)。治疗后,两组的全血高切黏度、血浆比黏度、血小板聚集率显著下降(P<0.05);且观察组各项血液流变学指标均低于对照组,差异有统计学意义(P<0.05)。结论丹参注射液联合生长抑素治疗急性胰腺炎的疗效确切,能进一步减轻临床症状,减轻炎症反应和改善血液流变学,安全性良好。

Objective To investigate the clinical efficacy of Danshen Injection combined with somatostatin in treatment of acute pancreatitis.Methods A total of 94 patients with acute pancreatitis admitted to Fuyang People’s Hospital from January 2018 to February 2021 were selected as the research subjects.According to the treatment methods,the patients were divided into control group and observation group,with 47 patients in each group.Patients in the control group were iv administered with Somatostatin for Injection,0.25 mg of which was fully diluted with 500 mL of normal saline,at the rate of 250μg/h,once daily.Patients in the observation group were iv administered with Danshen Injection on the basis of control group,adding 20 mL of normal saline with250 mL of normal saline to fully dilute the injection intravenously,once daily.Both groups were treated continuously for seven days.Clinical efficacy and recovery time of symptoms and signs in two groups were observed.Serum CRP,MCP-1,NLR,and amylase levels were compared before and after treatment in two groups.Results After treatment,the total effective rate of observation group was 95.74%,significantly higher than 82.98%of control group,the difference was statistically significant(P<0.05).After treatment,the recovery time of amylase and electrolyte,disappearance time of abdominal pain and disappearance time of abdominal distension in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CRP,MCP-1,NLR,and serum amylase in two groups were significantly decreased(P<0.05).After treatment,the levels of CRP,MCP-1,NLR,and amylase in observation group were significantly lower than those in control group(P<0.05).After treatment,the whole blood high cut viscosity,plasma specific viscosity,and platelet aggregation rate in two groups were significantly decreased(P<0.05).The whole blood high-cut viscosity,plasma specific viscosity,and platelet aggregation rate in the observation group were lower than those in the control group,with statistical significance(P<0.05).Conclusion Danshen Injection combined with somatostatin is effective in treatment of acute pancreatitis,which can further reduce clinical symptoms,alleviate inflammatory response and improve hemorheology,with good safety.