应用经典名方治疗变应性鼻炎的方药统计及用药规律分析

Statistics of syndrome differentiation and analysis of application rule of prescription in treating allergic rhinitis by clinicians

为了汇总分析临床医生使用古方治疗变应性鼻炎的概况,为进一步开展古方治疗鼻炎的现代临床应用及其药效学机制研究提供参考,检索中文学术期刊全文数据库(CNKI)、万方数据库(Wanfang Data)、维普中文期刊全文数据库(VIP)、中国生物医学文献数据库(CBM),时间为自建库至2020年11月16日,筛选变应性鼻炎的经验介绍、病例报道类文献,整理其古方、中药单味药等信息,运用SPSS Statistics 26.0、SPSS Modeler 18.0软件进行统计分析、关联规则分析、聚类分析、复杂网络分析。共纳入文献305篇,涉及267位医生或机构的治疗用药经验。使用频率较高的古方为玉屏风散(112)、桂枝汤(59)、麻黄细辛附子汤(49)等,功能类别以补益剂、解表剂、治风剂为主,高频药物为炙甘草、人参、茯苓等。关联规则体现了发表补虚的治法。聚类分析得到11组药物组合。复杂网络核心处方主要为桂枝汤和四君子汤。认为中医古方治疗变应性鼻炎多从肺脾肾入手,以补虚扶正为要,采用解肌发表、疏散外风、清热泻火等方法治疗,虚实兼顾,标本兼治。该研究可为临床医生运用中药复方治疗变应性鼻炎提供一定参考,为中医古方治疗变应性鼻炎的药效学机制研究提供思路。

To summarize and analyze the application of ancient herbal formula in the treatment of allergic rhinitis by traditional Chinese medicine(TCM),in order to provide a guidance for further researches on modern clinical applications and pharmacodynamic mechanisms against allergic rhinitis,the medical experiences and case reports about allergic rhinitis were collected from the databases of CNKI,VIP,Wanfang Data and CBM.The search time was limited from database creation to November 16,2020.Informations including related ancient herbal formula were collected.SPSS Statistics 26.0 and SPSS Modeler 18.0 software were used for statistical analysis,association rules,cluster analysis and complex network analysis.The highest usage frequency of ancient herbal formula was Yupingfeng San(112),followed by Guizhi Decoction(59),Mahuang Fuzi Xixin Decoction(49),and etc.Supplementing formula was the top one by classification of functions,followed by superficies-resolving formula,and formula for wind disorder.The highest usage frequency of TCM was baked licorice,ginseng,tuckahoe,and etc.Association rules embodied the treatment methods ofrelieving superficies and supplementing.In the cluster analysis,eleven groups of TCM combinations were obtained.The core prescription of complex network mainly consisted of Guizhi Decoction and Sijunzi Decoction.To treat allergic rhinitis with ancient prescriptions of TCM was mainly focused the lungs,spleen and kidney,so as to restore tonify deficiency.According to syndrome differentiation,there were many therapeutic methods used to treat allergic rhinitis such as releasing muscle,evacuating wind,clearing heat and reducing fire and so on,in order to treat both deficiency and excess,address both the symptoms and root causes.The paper may provide a guidance for clinicians in the treatment of allergic rhinitis,as well as offer a reference for pharmacodynamics mechanism study of TCM ancient prescriptions against allergic rhinitis.