不同孕期GDM孕妇CRP水平、HbA1c和维生素B12相关性研究

Correlation Study of CRP Level,HbA1c and Vitamin B12 in Pregnant Women with GDM in Different Pregnancy

目的:对不同孕期妊娠期糖尿病(gestational diabetes mellitus,GDM)孕妇的全血C反应蛋白(C-reactive protein,CRP)水平、糖化血红蛋白(glycosylated hemoglobin,Hb A1c)和血清维生素B12水平进行检测,并对其相关性进行分析。方法:以妊娠期孕妇为研究对象,根据OGTT试验结果分为对照组和研究组,对照组为健康孕妇,研究组为GDM孕妇,对两组中孕期和晚孕期孕妇的全血CRP、HbA1c和血清维生素B12进行检测。结果:研究组中孕期和晚孕期GDM的全血CRP和HbA1c水平均显著高于对照组(P<0.05)。与中孕期相比,两组晚孕期全血CRP水平均无明显变化(P>0.05),对照组孕妇全血HbA1c水平无明显变化(P>0.05),而研究组晚孕期全血HbA1c水平显著升高(P<0.05)。与对照组相比,研究组中孕期和晚孕期的血清维生素B12水平显著降低(P<0.05);与中孕期相比,对照组孕妇血清维生素B12水平无明显变化(P>0.05),而研究组晚孕期血清维生素B12水平显著降低(P<0.05)。研究组中孕期和晚孕期CRP水平与HbA1c呈显著的正相关,与维生素B12呈显著的负相关(P<0.05)。正常孕妇中孕期和晚孕期的CRP水平和HbA1c、维生素B12水平均未呈现相关性(P>0.05)。结论:GDM孕妇中孕期和晚孕期的全血CRP、Hb A1c和血清维生素B12均存在异常,且CRP水平与HbA1c显著正相关,与维生素B12水平显著负相关。

Objective:The whole blood CRP levels,HbA1 c and serum vitamin B12 levels of pregnant women with GDM in different pregnancy periods were detected,and their correlations were analyzed.Methods:Taking pregnant women as research subjects,they were divided into control group and study group according to the OGTT test results.The control group was healthy pregnant women and the study group was GDM pregnant women.The whole blood CRP levels,HbA1 c and serum vitamin B12 of pregnant women in the second and third trimesters of the two groups were tested.Results:The whole blood CRP and HbA1 c levels of GDM in the second and third trimesters of the study group were significantly higher than those of the control group(P<0.05).Compared with the second trimester,there was no significant change in the whole blood CRP level of the two groups in the third trimester(P>0.05),the whole blood Hb A1 c level of pregnant women in the control group did not change significantly(P>0.05),while the whole blood HbA1 c level of the study group was significantly increased in the third trimester(P<0.05).Compared with the control group,the serum vitamin B12 levels of the study group during the second and third trimesters were significantly reduced(P<0.05);compared with the second trimester,the serum vitamin B12 levels of pregnant women in the control group did not change significantly(P>0.05),while serum vitamin B12 level in the third trimester of the study group was significantly reduced(P<0.05).The CRP levels in the second and third trimesters of the study group were significantly positively correlated with Hb A1 c,and significantly negatively correlated with vitamin B12(P<0.05).There was no correlation between CRP levels and HbA1 c and vitamin B12 levels in normal pregnant women during the second and third trimesters(P>0.05).Conclusion:The whole blood CRP,HbA1 c and serum vitamin B12 of GDM pregnant women were abnormal in the second and third trimesters,and the CRP level was significantly positively correlated with HbA1 c,and significantly negatively correlated with the vitamin B12 level.