急性心肌梗死患者经皮冠状动脉介入术后血清磷酸肌醇3-激酶C2A mRNA表达量与预后的关系被引量：2

The relationship between serum phosphoinositol 3-kinase mRNA expression and prognosis in patients with acute myocardial infarction after percutaneous coronary intervention

下载PDF

导出

摘要目的探讨急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)术后血清磷酸肌醇3-激酶C2A(PIK3C2A)mRNA表达及与预后的关系。方法选取2016年5月至2018年6月北京市昌平区医院收治的187例接受PCI治疗的AMI患者作为研究对象。采用RT-qPCR法检测AMI患者血清PIK3C2A mRNA相对表达,并分析其与预后的关系。结果AMI患者PCI术后6个月共有22例(11.76%)发生预后不良。PCI术后预后不良组患者血清PIK3C2A mRNA相对表达量低于预后良好组(t=4.567,P<0.05)。PCI术后血清PIK3C2A mRNA评估AMI患者预后的AUC为0.845。Logistic多因素回归分析显示NYHA分级、冠状动脉病变支数、AMI至血管开通时间及PIK3C2A mRNA与心肌梗死患者PCI术后预后不良密切相关[OR(95%CI)=4.312(1.258~7.726)、4.109(1.022~7.307)、5.528(1.746~11.042)、4.857(1.437~9.113),P<0.05]。结论AMI患者PCI术后血清PIK3C2A mRNA相对表达与患者预后不良密切相关,检测血清PIK3C2A mRNA相对表达有助于评估患者预后。 Objective To investigate the expression of serum phosphoinositol 3-kinase C2A(PIK3C2A)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI)and its relationship with prognosis.Methods 187 AMI patients who received PCI treatment in Beijing Changping district hospital from May 2016 to June 2018 were selected as the research objects.The relative expression of PIK3C2A mRNA in serum of patients with AMI was detected by RT-q PCR,and the relationship between PI3Ks and prognosis was analyzed.Results A total of 22 patients(11.76%)with AMI had poor prognosis 6 months after PCI.The relative expression of PIK3C2A mRNA in patients with poor prognosis after PCI was lower than that in patients with good prognosis(t=4.567,P<0.05).The AUC of serum PIK3C2A mRNA evaluating prognosis of AMI after PCI was 0.845.Logistic multivariate regression analysis showed that NYHA classification,number of coronary lesion branches,time from AMI to vascular opening and PIK3C2A mRNA were closely related to poor prognosis of patients with AMI after PCI[OR(95%CI)=4.312(1.258-7.726),4.109(1.022-7.307),5.528(1.746-11.042),4.857(1.437-9.113);P<0.05].Conclusion The relative expression of PIK3C2A mRNA in serum after PCI in patients with AMI is closely related to poor prognosis.Detecting the relative expression of PIK3C2A mRNA in serum is helpful to evaluate the prognosis of patients with AMI.

作者向南坡吴铮 Xiang Nanpo;Wu Zheng(Department of Cardiology,Beijing Changping District Hospital,Beijing 102200,China;Department of Cardiology,Beijing Anzhen Hospital Affiliated to the Capital University of Medical Sciences,Beijing 100029,China)

机构地区北京市昌平区医院心内科首都医科大学附属北京安贞医院心内科

出处《心脑血管病防治》 2021年第5期469-471,487,共4页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

关键词急性心肌梗死经皮冠状动脉介入治疗磷酸肌醇3-激酶C2A 预后 Acute myocardial infarction Percutaneous coronary intervention Inositol phosphate 3-kinase C2A Prognosis

分类号 R542.22 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献6

1汪贵忠,赵胜,许恩文,欧阳星文,方昱,成威,赵文强.重组人尿激酶原冠状动脉内注射对行经皮冠状动脉介入术的急性心肌梗死患者的影响研究[J].实用心脑肺血管病杂志,2018,26(6):19-23. 被引量：23
2Qian-jie Tang,He-ping Lei,Hong Wu,Ji-yan Chen,Chun-yu Deng,Wang-sheng Sheng,Yong-heng Fu,Xiao-hong Li,Yu-bi Lin,Ya-ling Han,Shi-long Zhong.Plasma miR-142 predicts major adverse cardiovascular events as an intermediate biomarker of dual antiplatelet therapy[J].Acta Pharmacologica Sinica,2019,40(2):208-215. 被引量：6
3急性冠脉综合征急诊快速诊疗指南[J].中华急诊医学杂志,2016,25(4):397-404. 被引量：573
4申文彬,白静,杨霞,孙婷,汤喆,刘漠焓,任艺虹,王禹,苏绍萍.血小板高反应性对冠状动脉钙化患者介入术后发生主要不良心血管事件的研究[J].中华老年心脑血管病杂志,2016,18(2):153-157. 被引量：16
5袁秀,黄铮,洪承路,范俊.他汀联合依折麦布治疗急性冠脉综合征患者PCI术后的效果[J].实用医学杂志,2018,34(10):1708-1711. 被引量：25
6王霁翔,高静,任珉,孙博,刘寅.早期保护性肺通气和主动脉内球囊反搏联合急诊经皮冠状动脉介入治疗急性心肌梗死合并心源性休克的疗效[J].中华老年医学杂志,2017,36(7):724-729. 被引量：41

二级参考文献63

1Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC) [J]. Eur Heart J, 2016, 37 (3) : 267-315. DOI: 10. 1016/j. rec. 2015. 10. 009.
2Nabi F, Chang SM, Xu J, et al. Assessing risk in acute chest pain : The value of stress myocardial perfusion imaging in patients admitted through the emergency department [ J]. J Nucl Cardiol, 2012, 19 (2): 233-243. DOI: 10. 1007/s12350-011-9484-7.
3Shah BN, Balaji G, Alhajiri A, et al. Incremental diagnostic and prognostic value of contemporary stress echocardiography in a chest pain unit: mortality and morbidity outcomes from a real-world setting [J]. Cardiovasc Imaging, 2013, 6 (2): 202-209. DOI: 10. ll61/CIRCIMAGING. 112. 980797.
4Huhen E, Pickett C, Bittencourt MS, et al. Outcomes after coronary computed tomography angiography in theemergency department: a systematic review and meta-analysis of randomized, controlled trials [J]. J Am Coil Cardiol, 2013, 61 (8): 880- 892. DOI: 10. 1016/j. jacc. 2009. 02. 008.
5Mueller C, Giannitsis E, Christ M, et al. Multicenter evaluation of a 0-hour/l-hour algorithm in the diagnosis ofmyocardial infarction with high-sensitivity cardiac troponin T [ J ]. Ann Emerg Med, 2016, pii: S0196-0644 (15) 01501-2. DOI: 10. 1016/j. annemergrned. 2015. 11. 013.
6Reichlin T, Schindler C, Drexler B, et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T [J]. Arch Intern Med, 2012, 172 (16) : 1211-1218. DOI: 10. 1001/archintemmed. 2012. 3698.
7Steg PG, James SK, Atar D, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation [J]. Eur Heart J, 2012, 33 (20) : 2569-2619. DOI: 10. 1093/eurheartj/ehs215.
8Fox KA, Fitzgerald G, Puymirat E, et al. Should patients with acute coronary disease be stratified for management according to their risk Derivation, external validation and outcomes using the updated GRACE risk score [J]. BMJ Open, 2014, 4 (2): e4425. DOI: 10. 1136/bmjopen-2013-O04425.
9Abu-Assi E, Raposeiras-Roubin S, Iear P, et al. Comparing the predictive validity of three contemporary bleeding risk scores in acute coronary syndrome [J]. Eur Heart J Acute Cardiovasc Care, 2012, 1 (3): 222-231. DOI: 10. 1177/2048872612453924.
10Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes [ J ]. N Engl J Med, 2009, 361 (11): 1045-1057. DOI: 10. 1056/ NEJMoa0904327.