膝骨关节炎与膝关节周围骨密度的相关性研究进展

Research progress on relationship between knee osteoarthritis and bone mineral density around knee joint

膝骨关节炎(KOA)是以软骨退变及关节间隙变窄为主要特征的慢性、退行性疾病。骨密度(BMD)是指单位体积或面积的骨矿物质含量,是临床上用于反映骨质量的重要指标。全身BMD和膝关节BMD与KOA的分级,疼痛,生活质量及术后效果都有很密切的联系。尤其是膝关节BMD对于KOA的早期诊断、发展和预后都具有更为重要的意义,且二者的关系十分复杂,并成为近年来的研究热点,但目前膝关节BMD测量方法尚未统一,成为制约研究二者关系的瓶颈。本文对膝关节BMD与KOA的关系重点阐述,简要回顾并对比了近年来有关膝关节BMD测量方法,对今后相关研究提供参考和指导。

Knee osteoarthritis(KOA)is a chronic and slowly progressive joint disease characterized by cartilage degeneration and narrowing of joint space.It is the type with the highest incidence of osteoarthritis(OA).Bone mineral density(BMD)refers to the bone mineral content per unit volume or surface,which is an important index to reflect bone quality in clinic.There is a close relationship between whole body BMD and knee joint BMD and KOA grade,pain,quality of life and postoperative effect.In particular,knee joint BMD plays a more important role in the early diagnosis,development and prognosis of KOA,and the relationship between them is very complex and has become a research hotspot in recent years.But the measurement methods of knee joint BMD have not been unified.This paper focused on the relationship between knee joint BMD and KOA,briefly reviewed and compares the measurement methods of knee joint BMD in recent years,so as to provide reference and guidance for related research in the future.