血清Aβ42水平与脑白质病变的相关性研究

Correlation between serum Aβ42 level and white matter lesions

目的:探讨血清β淀粉样蛋白42(Aβ42)水平与脑白质病变(WML)的相关性。方法:选取2019年1月至2020年12月期间在南通大学附属南京江北医院神经内科住院的117例WML患者和同期在该医院住院的63例未发生WML的患者作为研究对象。为这些患者均使用头颅MRI技术确诊其是否患有WML。将患有WML的患者作为WML组,将未患有WML的患者作为对照组。根据WML组患者进行头颅MRI检查的结果及Fazekas量表的评分将其分为重度WML组和轻度WML组。检测各组患者血清Aβ42等多项生化指标的水平。然后观察各组患者的一般资料、血清Aβ42水平与WML发生情况的相关性、血清Aβ42的水平与WML严重程度的相关性。结果:WML组患者的年龄大于对照组患者,其中高血压患者的占比、其血浆同型半胱氨酸(Hcy)及血清Aβ42的水平均高于对照组患者,P<0.05。年龄是导致这些患者发生WML的独立影响因素。这些患者血清Aβ42的水平与其发生WML的情况无相关性。重度WML组患者血清Aβ42的水平高于轻度WML组患者,P<0.05。WML患者血清Aβ42水平与其WML的严重程度呈正相关。结论:与未发生WML的患者相比,WML患者血浆Hcy的水平及血清Aβ42的水平均较高,年龄较大,其中高血压患者的占比较高,血清Aβ42的水平与其WML的严重程度呈正相关。

Objective:To investigate the correlation between serum amyloid beta 42(Aβ42)level and white matter lesions(WML).Methods:A total of 117 WML patients hospitalized in the Department of Neurology,Nanjing Jiangbei Hospital,Affiliated to Nantong University from January 2019 to December 2020 and 63 patients without WML in the hospital during the same period were selected as the study subjects.All of these patients were diagnosed with WML using head MRI.Patients with WML were included in the WML group and those without WML were included in the control group.Patients in the WML group were divided into severe WML group and mild WML group according to the results of head MRI examination and Fazekas scale score.Serum Aβ42 and other biochemical indexes were detected in each group.Then,the general information,the correlation between serum Aβ42 level and the occurrence of WML,and the correlation between serum Aβ42 level and the severity of WML in each group were observed.Results:The age of patients in WML group was older than that in control group,and the proportion of patien ts with hypertension,plasma homocysteine(Hcy)and serum Aβ42 were higher than those in control group,P<0.05.Age was an independent predictor of WML in these patients.There was no correlation between serum Aβ42 levels and WML occurrence in these patients.The level of serum Aβ42 in severe WML group was higher than that in mild WML group,P<0.05.The level of serum Aβ42 was positively correlated with the severity of WML.Conclusions:Compared with patients without WML,the level of plasma Hcy and serum Aβ42 in WML patients were higher and older,and the proportion of patients with hypertension was higher.The level of serum Aβ42 was positively correlated with the severity of WML.