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螺旋断层调强放疗联合顺铂治疗局部晚期鼻咽癌的临床疗效 被引量:4

Clinical efficacy of helical tomography combined with cisplatin in the treatment of locally advanced nasopharyngeal carcinoma
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摘要 目的探究螺旋断层调强放疗(helical tomotherapy,TOMO)联合顺铂治疗局部晚期鼻咽癌的临床疗效。方法选取2019年3月至2020年7月本院收治的63例晚期鼻咽癌患者作为研究对象,按照随机数字表法分为研究组(n=32)和对照组(n=31)。对照组采用顺铂治疗,研究组在对照组基础上联合TOMO治疗。比较两组临床疗效、不良反应发生率、T淋巴细胞亚群水平、QLQ-C30评分。结果研究组ORR高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。治疗后,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于治疗前,CD8^(+)均低于治疗前,且研究组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均明显高于对照组,CD8^(+)明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组情绪功能、躯体功能、角色功能、认知功能、社会功能评分均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。结论TOMO联合顺铂治疗局部晚期鼻咽癌疗效显著,具有较高安全性,值得临床推广应用。 Objective To explore the clinical efficacy of helical tomotherapy (TOMO) combined with cisplatin in the treatment of locally advanced nasopharyngeal carcinoma.Methods 63 patients with advanced nasopharyngeal carcinoma admitted to our hospital from March 2019 to July2020 were selected as the research subjects,and they were divided into study group (n=32) and control group (n=31) according to the random number table method.The control group was treated with cisplatin,and the study group was combined with TOMO treatment on the basis of the control group.The clinical efficacy,the incidence of adverse reactions,the level of T lymphocyte subsets,and the QLQ-C30 score were compared between the two groups.Results The ORR of the study group was higher than that of the control group,and the difference was statistically significant (P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.After treatment,the two groups of CD3^(+),CD4^(+),CD4^(+)/CD8^(+) were higher than before treatment,CD8^(+) were lower than before treatment,and CD3^(+),CD4^(+),CD4^(+)/CD8^(+) in the study group were significantly higher than the control group,CD8^(+) was significantly lower than the control group,the difference was statistically significant (P<0.05).After treatment,the emotional function,physical function,role function,cognitive function,and social function scores of the two groups were higher than those before treatment,and the study group was higher than the control group,the difference was statistically significant (P<0.05)Conclusion TOMO combined with cisplatin is effective in the treatment of locally advanced nasopharyngeal carcinoma,with high safety,and it is worthy of clinical application.
作者 万强琨 WAN Qiangkun(Department of Radiotherapy,First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui,233000,China)
出处 《当代医学》 2021年第34期18-21,共4页 Contemporary Medicine
基金 蚌埠医学院科研课题(BYKY17110)。
关键词 鼻咽癌 晚期 螺旋断层调强放疗 顺铂 T淋巴细胞亚群 生活质量 Nasopharyngeal carcinoma Advanced Helical tomotherapy Cisplatin T lymphocyte subsets Quality of life
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