玫瑰痤疮与恶性肿瘤相关性的meta分析

Meta analysis of relationship between rosacea and malignant tumor

目的分析玫瑰痤疮患者合并恶性肿瘤风险大小。方法检索PubMed、Cochrane library、Web of science、Embase、CNKI数据库,收集所有研究玫瑰痤疮与恶性肿瘤相关性的队列研究、病例对照研究,检索截至2020年11月,由2名研究者对符合纳入条件的文献进行质量评价、提取数据。结果共纳入3个病例对照研究和4个队列研究。病例对照研究的meta分析结果显示:玫瑰痤疮发生消化道肿瘤的风险低于对照人群[OR=0.91,95%CI(0.83,0.99),P=0.03]。队列研究的meta分析结果显示:玫瑰痤疮会增加乳腺癌[HR=1.08,95%CI(1.00,1.16),P=0.04]和非黑素瘤恶性皮肤癌(NMSC)[HR=1.32,95%CI(1.14,1.53),P<0.05]的患病风险,玫瑰痤疮患者发生肝胆癌、肺癌、甲状腺癌、皮肤恶性黑色素瘤(MM)的风险与普通人群无明显差异(P≥0.05)。结论玫瑰痤疮患者发生NMSC和乳腺癌的风险增高,发生消化道肿瘤的风险降低,而与肺癌、肝胆癌、甲状腺癌、MM无相关性。

Objective To analyze the risk of the patients with rosacea complicating malignant tumor.Methods All cohort studies and case-control studies on the relationship between rosacea and malignant tumors were collected by retrieving the databases of PubMed,Web of science,Embase,CNKI and Cochrane library until November 2020.Two researchers conducted the quality evaluation of the literature meeting the inclusion condition and extracted the data.Results A total of 3 case-control studies and 4 cohort studies were included.The meta-analysis results of the case-control study showed that the risk of digestive tract cancer occurrence in the patients with rosacea was lower than that in the general population[OR=0.91,95%CI(0.83,0.99),P=0.03].The meta-analysis results of the cohort study showed that rosacea increased the risk of breast cancer[HR=1.08,95%CI(1.00,1.16),P=0.04]and nonmelanoma malignant skin cancer(NMSC)[HR=1.32,95%CI(1.14,1.53),P<0.05].There was no significant difference in the risk of hepatobiliary cancer,lung cancer,thyroid cancer and malignant melanoma(MM)between the patients with rosacea and the general population(P≥0.05).Conclusion The risk of NMSC and breast cancer occurrence in the patients with rosacea is increased,and the risk of digestive tract tumor occurrence is decreased,but there is no significant correlation with lung cancer,hepatobiliary cancer,thyroid cancer and MM.