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基于小样本甲状腺高b值扩散加权成像影像组学的机器学习在鉴别诊断结节型桥本甲状腺炎与甲状腺微小乳头状癌中的应用 被引量:7

Machine Learning-Based Small Sample High b-Value Diffusion Weighted Imaging Radiomics in the Differential Diagnosis of Nodular Hashimoto's Thyroiditis and Papillary Thyroid Microcarcinoma
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摘要 目的探讨小样本甲状腺高b值扩散加权成像(DWI)影像组学分类模型鉴别诊断结节型桥本甲状腺炎(NHT)与甲状腺微小乳头状癌(PTMC)的价值。资料与方法回顾性纳入经病理证实的40例46个NHT和48例61个PTMC甲状腺高b值DWI,对结节进行分割、特征值提取,并使用3种特征值标准化、2种降维、3种特征值筛选方法确定影像组学特征值,采用受试者工作特征(ROC)曲线和曲线下面积(AUC)分析10种分类模型对两种病变的鉴别诊断效能。结果46个NHT和61个PTMC共提取了107个影像组学特征值。当选择Normalize to unit(NormUnit)进行标准化、主成分分析进行降维、ANOVA进行特征值筛选,在15个特征值时,线性判别分析分类模型鉴别诊断NHT与PTMC效果最优,准确度为85.71%,敏感度为80.00%,特异度为100.00%,AUC值为0.925。结论小样本甲状腺高b值DWI影像组学分类模型对于NHT和PTMC具有鉴别诊断价值。 Purpose To evaluate the role of machine-learning model based small sample high b-value diffusion weighted imaging(DWI)radiomics in differentiation between nodular Hashimoto's thyroiditis(NHT)and papillary thyroid microcarcinoma(PTMC).Materials and Methods Thyroid high b-value DWI of 46 NHT in 40 patients and 61 PTMC in 48 patients confirmed by pathology were selected into this retrospective study.After nodules segmentation and radiomics features extraction,3 features'standardizations,2 features'dimensionality reductions,3 features'selections and 10 classification models were used to select radiomics features and comparison analysis on the 10 classification models for differential diagnosis between NHT and PTMC was carried out,the receiver operator characteristic(ROC)curve and the area under curve(AUC)were further drawn and the diagnostic efficiency was compared.Results A total of 107 radiomics features were extracted from the 46 NHT and 61 PTMC.When features standardization of Normalize to unit(NormUnit),features dimensionality reduction of principal component analysis(PCA)and features selection of analysis of variance(ANOVA)were used and 15 radiomics features were selected,the classification model of linear discriminant analysis had the best diagnostic efficiency in differentiating PTMC from NHT with accuracy of 85.71%,sensitivity of 80.00%,specificity of 100.00%and AUC of 0.925 in the test set,respectively.Conclusion The machine-learning model based small sample high b-value DWI radiomics contributes to differentiation between NHT and PTMC.
作者 王庆军 石清磊 袭肖明 符永瑰 逯巧慧 任贺 WANG Qingjun;SHI Qinglei;XI Xiaoming;FU Yonggui;LU Qiaohui;REN He(Department of Ultrasound,the 6th Medical Center of Chinese PLA General Hospital,Beijing 100048,China;不详)
出处 《中国医学影像学杂志》 CSCD 北大核心 2021年第11期1064-1069,1075,共7页 Chinese Journal of Medical Imaging
关键词 甲状腺肿瘤 乳头状 甲状腺炎 磁共振成像 扩散加权成像 影像组学 机器学习 病理学 外科 诊断 鉴别 Thyroid neoplasms Carcinoma,papillary Thyroiditis Magnetic resonance imaging Diffusion weighted imaging Radiomics Machine learning Pathology,surgical Diagnosis,differential
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  • 1Catmregli P,De Remigis A,Rose NR.Hashimoto thyroiditis:clinical and diagnostic criteria[J].Autoimmun Rev,2014,13(4-5):391-397.
  • 2Teng W,Shan Z,Teng X,et al.Effect of iodine intake on thyroid diseases in China[J].N Engl J Med,2006,354(26):2783-2793.
  • 3Teng X,Shan Z,Chen Y,et al.More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis:a cross-sectional study based on two Chinese communities with different iodine intake levels[J].Eur J Endocrinol,2011,164(6):943-950.
  • 4Kontmrek A,Barczynski M,Wierzchowski W,et al.Coexistence of papillary thyroid cancer with Hashimoto thyroiditis[J].Langenbecks Amh Smrg,2013,398 (3):389-394.
  • 5Chen YK,Lin CL,Cheng FT,et al.Cancer risk in patients with Hashimoto's thymiditis:a nationwide cohort study[J].Br J Cancer,2013,109(9):2496-2501.
  • 6Kwak JY,Jung I,Baek JH,et al.Image repmting and characterization system for ultrasound features of thyroid nodules:multicentric Korean retrospective study[J].Korean J Radiol,2013,14(1):110-117.
  • 7American Thyroid Association Guidelines Taskfome on Thyroid N,Differentiated Thyroid C,Cooper DS,et al.Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer[J].Thyroid,2009,19(11):1167-1214.
  • 8Kim KW,Park YJ,Kim EH,et al.Elevated risk of papillary thyroid cancer in Korean patients with Hashimoto' s thyroiditis[J].Head Neck,2011,33(5):691-695.
  • 9Fiore E,Rago T,Latmfa F,et al.Hashimoto' s thyroiditis is associated with papillmy thyroid caminoma:role of TSH and of treatment with L-thyroxine[J].Endocr Relat Cancer,2011,18(4):429-437.
  • 10Haymart MR,Repplinger DJ,Levmson GE,et al.Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage[J].J Clin Endocrinol Metab,2008,93(3):809-814.

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