前列地尔注射液治疗缺血性肠病患者的效果

Effects of Alprostadil injection in treatment of patients with ischemic bowel disease

目的:观察前列地尔注射液治疗缺血性肠病患者的效果。方法:选取72例缺血性肠病患者作为研究对象,按随机数字表法分为对照组和研究组各36例。对照组采用常规治疗,研究组在对照组基础上采用前列地尔注射液治疗,比较两组临床疗效、肠相关功能恢复时间,血清肠型脂肪酸结合蛋白(IFABP)、二胺氧化酶(DAO)水平和不良反应发生率。结果:研究组治疗总有效率为91.67%(33/36),高于对照组的72.22%(26/36),差异有统计学意义(P<0.05);治疗后,研究组肠供血恢复时间、肠功能恢复时间、腹痛缓解时间和便血消失时间均短于对照组,IFABP、DAO水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗的基础上采用前列地尔注射液治疗缺血性肠病患者可提高治疗总有效率,缩短肠相关功能恢复时间,降低IFABP、DAO水平,效果优于单纯常规治疗。

Objective:To observe effects of Alprostadil injection in treatment of patients with ischemic bowel disease.Methods:72 patients with ischemic bowel disease were selected as the research objects,and were divided into control group and study group according to the random number table method,36 cases in each group.The control group was treated with conventional treatment,while the study group was treated with Alprostadil injection on the basis of that of the control group.The clinical efficacy,the intestinal function recovery time,the serum intestinal fatty acid binding protein(IFABP)and diamine oxidase(DAO)levels and incidence of adverse reactions were compared between the two groups.Results:The effective rate of treatment in the study group was 91.67%(33/36),which was higher than 72.22%(26/36)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the recovery time of intestinal blood supply,the recovery time of intestinal function,the relief time of abdominal pain and the disappearance time of bloody stool of the study group were shorter than those of the control group;the IFABP and DAO levels were lower than those of the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of conventional treatment,Alprostadil injection in the treatment of the patients with ischemic bowel disease can increase the effective rate of treatment,shorten the recovery time of intestinal functions,and reduce the levels of IFABP and DAO.Moreover,it is superior to single conventional treatment.