复方嗜酸乳杆菌联合美沙拉嗪治疗溃疡性结肠炎患者的效果

Effects of compound Lactobacillus acidophilus combined with Mesalazine in treatment of patients with ulcerative colitis

目的:观察复方嗜酸乳杆菌联合美沙拉嗪治疗溃疡性结肠炎患者的效果。方法:选取87例溃疡性结肠炎患者作为研究对象,按随机数字表法分为对照组(n=44)与观察组(n=43)。对照组采用美沙拉嗪肠溶片治疗,观察组在对照组基础上采用复方嗜酸乳杆菌片治疗,比较两组治疗前后炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平、肠黏膜屏障功能指标(D-乳酸、二胺氧化酶)水平和不良反应发生率。结果:治疗后,观察组TNF-α、IL-6水平均低于对照组,差异有统计学意义(P<0.05);观察组D-乳酸、二胺氧化酶水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:复方嗜酸乳杆菌联合美沙拉嗪治疗溃疡性结肠炎患者可降低炎性因子水平和肠黏膜屏障功能指标水平,其效果优于单纯美沙拉嗪肠溶片治疗。

Objective:To observe effects of compound Lactobacillus acidophilus combined with Mesalazine in treatment of patients with ulcerative colitis.Methods:87 patients with ulcerative colitis were selected as the research objects,and were divided into control group(n=44)and observation group(n=43)according to the random number table.The control group was treated with Mesalazine enteric-coated tablets,while the observation group was treated with Lactobacillus acidophilus compound tablets on the basis of that of the control group.The levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],the mucosal barrier function index levels(D-lactic acid,diamine oxidase)and the incidence of adverse effects before and after the treatment were compared between the two groups.Results:After the treatment,the levels of TNF-αand IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of D-lactic acid and diamine oxidase in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compound Lactobacillus acidophilus combined with Mesalazine in the treatment of the patients with ulcerative colitis can reduce the levels of inflammatory factors and the levels of intestinal mucosal barrier function indexes.Moreover,it is superior to single Mesalazine entericcoated tablets.