加贝酯联合奥曲肽与奥美拉唑对镜下逆行胰胆管造影术后患者并发症的预防效果

Effects of triple therapy of Gabexate,Octreotide and Omeprazole in prevention of complications of patients after endoscopic retrograde cholangiopancreatography

目的:观察加贝酯联合奥曲肽与奥美拉唑对镜下逆行胰胆管造影(ERCP)术后患者并发症的预防效果。方法:选取146例ERCP术后患者为研究对象,按照随机数字表法分为对照组和观察组各73例。对照组给予奥曲肽联合奥美拉唑治疗,观察组在对照组基础上加用加贝酯治疗。比较两组手术前后血清淀粉酶(AMY)水平,高淀粉酶血症(HP)和胰腺炎发生率,以及不良反应发生率。结果:术后6 h、12 h、1 d,两组血清AMY水平均高于术前,但观察组低于对照组,差异有统计学意义(P<0.05);观察组HP和胰腺炎发生率均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:加贝酯联合奥曲肽与奥美拉唑可降低ERCP术后患者血清AMY水平、HP发生率和胰腺炎发生率,优于奥曲肽联合奥美拉唑治疗效果。

Objective:To observe effects of triple therapy of Gabexate,Octreotide and Omeprazole in prevention of complications of patients after endoscopic retrograde cholangiopancreatography(ERCP).Methods:146 patients after ERCP were selected as the research objects,and were divided into control group and observation group according to the random number table method,73 cases in each group.The control group was treated with Octreotide combined with Omeprazole,while the observation group was treated with Gabexate on the basis of that of the control group.The serum AMY level,the incidence of hyperamylasemia(HP)and pancreatitis,and the incidence of adverse reactions were compared between the two groups before and after the surgery.Results:6 h,12 h,and 1 d after the surgery,the serum AMY levels of the two groups were higher than those before the surgery;those of the observation group were lower than those of the control group;and the differences were statistically significant(P<0.05).The incidence of HP and pancreatitis in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusions:The triple therapy of Gabexate,Octreotide and Omeprazole can reduce the serum AMY level and the incidence of HP and pancreatitis in the patients after ERCP.Moreover,it is superior to Octreotide combined with Omeprazole.