小剂量多巴胺联合多巴酚丁胺治疗新生儿硬肿症的效果

Effects of low-dose Dopamine combined with Dobutamine in treatment of scleredema neonatorum

目的:观察小剂量多巴胺联合多巴酚丁胺治疗新生儿硬肿症(SN)的效果。方法:回顾性分析2017年5月至2019年12月该院收治的66例SN患儿的临床资料,根据用药方案不同分为观察组和对照组各33例。对照组给予多巴酚丁胺治疗,观察组在对照组的基础上联合小剂量多巴胺治疗,比较两组患儿临床疗效、康复指标水平、肾功能指标[血清胱抑素C(Cys-C)、血尿素氮(BUN)及血肌酐(SCr)]水平和不良反应发生率。结果:观察组治疗总有效率为96.97%(32/33),显著高于对照组的78.79%(25/33),差异有统计学意义(P<0.05);观察组反应好转时间、硬肿消退时间、肛温恢复正常时间及住院时间均显著短于对照组,差异有统计学意义(P<0.05);治疗后,观察组Cys-C、BUN、SCr水平和对照组Cys-C水平显著低于治疗前,且观察组各指标水平显著低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:小剂量多巴胺联合多巴酚丁胺治疗SN患儿效果显著,可加快症状缓解,缩短住院时间,改善患儿肾功能,效果优于单用多巴酚丁胺。

Objective:To observe effects of low-dose Dopamine combined with Dobutamine in treatment of scleredema neonatorum(SN).Methods:The clinical data of 66 children with SN admitted to the hospital from May 2017 to December 2019 were retrospectively analyzed.According to the different medication regimens,they were divided into observation group and control group with 33 cases each.The control group was treated with Dobutamine,while the observation group was combined with low-dose Dopamine on the basis of that of the control group.The clinical efficacy,the rehabilitation indicator levels,the renal function indicator levels[serum cystatin C(Cys-C),blood urea nitrogen(BUN)and blood creatinine(SCr)]levels and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.97%(32/33),which was significantly higher than 78.79%(25/33)of the control group,and the difference was statistically significant(P<0.05).The improved response time,the hard swelling remission time,the time to normal rectal temperature and the hospitalization time in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of Cys-C,BUN,and SCr in the observation group and Cys-C in the control group were significantly lower than those before the treatment;those of the observation group were significantly lower than those of the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusions:Low-dose Dopamine combined with Dobutamine has a significant effect in the treatment of the children with SN,which can accelerate the relief of the symptoms,shorten the hospitalization time,and improve the renal function.Moreover,it is superior to single Dobutamine.