冰溪皮肤屏障修复乳联合0.03%他克莫司软膏治疗玫瑰痤疮患者的临床效果

Effects of Binsis skin barrier repair lotion combined with Tacrolimus ointment in treatment of rosacea

目的:观察冰溪皮肤屏障修复乳联合0.03%他克莫司软膏治疗玫瑰痤疮患者的效果。方法:选取100例玫瑰痤疮患者作为研究对象,以随机数字表法将其分为观察组和对照组各50例。对照组采用0.03%他克莫司软膏治疗,观察组在对照组基础上联合冰溪皮肤屏障修复乳治疗,比较两组临床疗效、临床症状评分和随访3个月复发率。结果:观察组治疗有效率为98.00%(49/50),高于对照组的84.00%(42/50),差异有统计学意义(P<0.05);治疗后,观察组丘疹脓疱、瘙痒和红斑等临床症状评分均低于对照组,差异有统计学意义(P<0.05);观察组复发率为2.00%(1/50),低于对照组的18.00%(9/50),差异有统计学意义(P<0.05)。结论:冰溪皮肤屏障修复乳联合0.03%他克莫司软膏治疗玫瑰痤疮患者可提高治疗总有效率,降低临床症状评分和复发率,效果优于单纯他克莫司软膏治疗。

Objective:To observe effects of Binsis skin barrier repair lotion combined with Tacrolimus ointment in treatment of rosacea.Methods:100 rosacea patients were selected as the research objects,and were divided into observation group and control group by using the random number table method,50 cases in each group.The control group was treated with Tacrolimus ointment,while the observation group was treated with Binsis skin barrier repair lotion on the basis of that of the control group.The clinical efficacy,the clinical symptom score and the recurrence rate at three-month follow-up were compared between the two groups.Results:The effective rate of treatment in the observation group was 98.00%(49/50),which was higher than 84.00%(42/50)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of clinical symptoms such as papules,pustules,itching,and erythema in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the recurrence rate in the observation group was 2.00%(1/50),which was lower than 18.00%(9/50)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Binsis skin barrier repair lotion combined with Tacrolimus ointment in the treatment of the rosacea patients can improve the effective rate of treatment and reduce the clinical symptom score and the recurrence rate.Moreover,it is superior to single Tacrolimus ointment.