细胞微颗粒与冠心病:利还是弊?

Microparticles and cornoary heart disease:friend or foe?

微颗粒(microparticles,MPs)是细胞在应激或损伤条件下,从质膜脱落到胞外的微小膜性囊泡。不同细胞来源的MPs,除对炎症、凝血、肿瘤等有影响外,在冠心病中的作用也受到广泛关注。有利的方面,在冠心病的发生发展过程中,具有保护心肌的作用,并且MPs循环浓度及表面标志可区分不同类型、不同程度的冠心病,故可作为区分疾病和判断损伤程度的标志。有弊的方面,MPs直接或间接参与内皮功能恶化、血栓形成和心肌损伤等一系列病理过程,与冠心病发生、发展的进程密切相关,有望作为干预和治疗的潜在靶点。

Microparticles(MPs)are small membranous vesicles that are shed from membrane to extracellular under stress or injury.In addition to the effects on inflammation,coagulation,tumor,and so on,the role of different cell-derived microparticles in coronary heart disease has also been widely concerned.On the positive side,it can protect the myocardium in the occurrence and development of coronary heart disease,and MPs circulating concentration and surface markers can distinguish different types and degrees of coronary heart disease,so it can be used as a marker to distinguish diseases and judge the degree of injury.On the down side,MPs directly or indirectly are involved in a series of pathological processes such as endothelial function deterioration,thrombosis,and myocardial injury.It is closely related to the occurrence and development of coronary heart disease and is expected to be a potential target for intervention and treatment.