老年慢性冠状动脉综合征患者调节性T细胞与血清脂蛋白(a)的相关性研究

Relationship between regulatory T cells and serum lipoprotein(a)in elderly patients with chronic coronary syndrome

目的:探讨老年慢性冠状动脉综合征患者调节性T细胞水平与血清脂蛋白a[Lp(a)]的相关性。方法:入选年龄≥65岁的慢性冠状动脉综合征患者,且低密度脂蛋白胆固醇(LDL-C)水平已达治疗目标值;根据Lp(a)水平筛选血清Lp(a)正常组(0~300 mg/L)及血清Lp(a)升高组(>300 mg/L);检测两组患者外周血中调节性T细胞及炎性标志物的水平,并进行差异性及相关性分析。结果:血清Lp(a)升高组外周血调节性T细胞及抗炎细胞因子的表达明显降低,致炎细胞因子明显升高(均P<0.05);血清Lp(a)与调节性T细胞的表达、炎性标志物明显相关。结论:血清Lp(a)可能通过调控调节性T细胞的表达参与老年慢性冠状动脉综合征患者的免疫炎症失衡。

Objective:To investigate the correlation between the expression of regulatory T cells and serum lipoprotein(a)in elderly patients with the chronic coronary syndrome.Methods:Patients aged≥65 years with chronic coronary syndrome were enrolled,and the level of low-density lipoprotein cholesterol(LDL-C)reached the therapeutic target.According to the level of lipoprotein(a),all patients were divided into two groups:the normal serum lipoprotein(a)group(0-300 mg/L)and the elevated serum lipoprotein(a)group(>300 mg/L).The levels of regulatory T cells and inflammatory markers in peripheral blood were detected,and the differences and correlations were analyzed.Results:The expression of regulatory T cells and anti-inflammatory cytokines in peripheral blood were significantly decreased.In contrast,the inflammatory cytokines were significantly increased in the elevated serum lipoprotein(a)group(P<0.05).The serum lipoprotein(a)was significantly correlated with regulatory T cells and inflammatory markers.Conclusion:Serum lipoprotein(a)may be involved in immuno-inflammatory imbalance by regulating the expression of regulatory T cells in elderly patients with chronic coronary syndromes.