体检人群脑白质高信号与脑血管血流动力学积分的关系

Relationship between white matter hyperintensity and cerebrovascular hemodynamic index accumulative score in health examination population

目的观察体检人群脑白质高信号(white matter hyperintensity,WMH)检出率,探讨体检人群发生WMH的影响因素。方法561例体检者均行颅脑MRI检查评估WMH,行脑血管血流动力学监测计算脑血管血流动力学指标(cerebrovascular hemodynamic index,CVHI)积分。根据WMH检出情况,将561例体检者分为WMH组和对照组,比较2组一般资料,血清同型半胱氨酸、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖水平及CVHI积分;Pearson相关法分析年龄与CVHI积分的相关性;多因素logistic回归分析体检人群发生WMH的影响因素。结果561例体检者中335例(59.71%)检出WMH。WMH组年龄[(53.11±10.28)岁]大于对照组[(49.26±11.38)岁](P<0.05),男性比率(75.82%)、CVHI积分[(72.16±26.23)分]均低于对照组[82.74%、(79.17±22.08)分](P<0.05),体质量指数、收缩压、舒张压及血清同型半胱氨酸、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、空腹血糖水平与对照组比较差异均无统计学意义(P>0.05)。561例体检者、对照组、WMH组年龄与CVHI积分均呈负相关(r=-0.359,P<0.001;r=-0.308,P<0.001;r=-0.370,P<0.001)。年龄(OR=1.026,95%CI:1.008~1.044,P=0.005)、CVHI积分(OR=0.992,95%CI:0.984~0.999,P=0.037)是体检人群发生WMH的影响因素。结论年龄、CVHI积分与体检人群检出WMH有关。

Objective To observe the detective rate of white matter hyperintensity(WMH)and to explore the influencing factors of WMH in health examination population.Methods All 561 healthy examination subjects underwent cerebral MRI and cerebrovascular function examination to detect the cerebrovascular hemodynamic index(CVHI)accumulative score.According to the detection of WMH,561 healthy examination subjects were divided into WMH group and control group,and were compared the general clinical data,the levels of serum homocysteine,total cholesterol,triacylglycerol,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol and fasting plasma glucose,as well as the CVHI accumulative score between two groups.Pearson correlation analysis was used to study the correlation of age with CVHI accumulative score.Multivariate logistic regression was used to assess the influencing factors of WMH in heath examination population.Results In 561 subjects,335(59.71%)were detected WMH.The subjects were older in WMH group[(53.11±10.28) years]than those in control group[(49.26±11.38)years](P<0.05).The percentage of males and CVHI accumulative score were lower in WMH group(75.82%,72.16±26.23)than those in control group(82.74%,79.17±22.08)(P<0.05).There were no significant differences in body mass index,systolic blood pressure,diastolic blood pressure,and the levels of serum homocysteine,total cholesterol,triacylglycerol,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol and fasting plasma glucose between two groups(P>0.05).The age was negatively correlated with CVHI accumulative score in 561 health examination subjects(r=-0.359,P<0.001),control group(r=-0.308,P<0.001)and WMH group(r=-0.370,P<0.001).The age(OR=1.026,95%CI:1.008-1.044,P=0.005)and CVHI accumulative score(OR=0.992,95%CI:0.984-0.999,P=0.037)were the influencing factors of WMH.Conclusion The age and CVHI accumulative score might be correlated with WMH in health examination subjects.