HPV在口咽鳞癌的临床意义

Clinical Significance of HPV in Oropharyngeal Squamous Cell Carcinoma

目的探讨HPV与口咽鳞癌的临床意义。方法选择2010年1月至2019年12月在云南省肿瘤医院诊治并符合入组标准的129例口咽癌患者作为研究对象。使用HPV16/18型DNA探针、HPV 6/11型DNA探针对收集的病理标本进行检测。采用SPSS 24.0统计软件进行数据分析。结果HPV阳性率39.53%,全部为高危型HPV 16/18感染;扁桃体区及舌根区阳性率最高;HPV阳性组中发病年龄小于60岁(P=0.041)、分期为早期(P=0.001)的病例数明显多于阴性组。而阴性组中长期吸烟病例数明显高于阳性组(P=0.012)。HPV阳性组的患者治疗有效率高于阴性组。结论HPV阳性口咽鳞癌患者较HPV阴性口咽鳞癌患者发病年龄年轻、分期早、长期吸烟人数少,且对放化疗敏感性更高。

Objective To explore the clinical significance of HPV in oropharyngeal squamous cell carcinoma.Methods A total of 129 patients who were diagnosed and treated in Yunnan Tumor Hospital and met the inclusion criteria in oropharyngeal cancer from January 2010 to December 2019 were selected as the research subjects.The collected pathological specimens were detected using HPV16/18 DNA probes and HPV 6/11 DNA probes.SPSS 24.0 statistical software was used for data analysis.Results The positive rate of HPV in this study was 39.53%,all of which were high-risk HPV 16/18 infection.The positive rate was highest in tonsil area and tongue root area.The number of cases with the onset age less than 60 years(P=0.041)and the early stage(P=0.001)in the HPV positive group was significantly higher than that in the negative group.The number of long-term smoking cases in the negative group was significantly higher than that in the positive group(P=0.012).The treatment effective rate of patients in the HPV positive group is higher than that in the HPV negative group.Conclusion Compared with HPV-negative oropharyngeal squamous cell carcinoma,patients with HPV-positive oropharyngeal squamous cell carcinoma have a younger onset,early stage,fewer long-term smokers,and are more sensitive to radiotherapy and chemotherapy.