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降钙素受体、维生素D受体基因多态性与昆明地区2型糖尿病合并骨质疏松的关系 被引量:2

Relationship between Calcitonin Receptor,Vitamin D Receptor Gene Polymorphism and Type 2 Diabetes Mellitus with Osteoporosis in Kunming Area
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摘要 目的研究降钙素受体(CTR)、维生素D受体(VDR)基因多态性与昆明地区2型糖尿病(T2DM)伴骨质疏松症的关系,探讨T2DM伴骨质疏松症发病的遗传易感因素。方法收集2017年6月至2019年1月在昆明市第一人民医院内分泌科住院的T2DM患者237例。(1)按骨密度结果分组为T2DM无骨质疏松组(61例),T2DM合并骨量减少组(111例),T2DM伴骨质疏松组(65例),采用PCR-RFLP技术,检测CTR和VDR基因型,比较3组患者以下指标间的差异:CTR和VDR基因型及等位基因频率,性别、年龄、糖尿病病程、血压、身高、体重、体重指数(BMI)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血钙、血脂、血尿酸(UA)、维生素D浓度、雌激素、睾酮水平,超敏C-反应蛋白(Hs-CRP)、纤维蛋白原(FIB),口服葡萄糖耐量(OGTT)-0 h、2 h血糖,0 h、2 h胰岛素(INS)水平,胰岛素抵抗指数(HOMA-IR);(2)比较CTR联合VDR不同基因型组合间骨密度的差异;(3)将CTR联合VDR基因型组合及组间具有统计学差异的指标进行多因素Logistic回归分析。结果(1)3组患者比较,CTR联合VDR不同基因型组合差异均无统计学意义(P>0.05);(2)CTR联合VDR 3种基因型组合比较,各部位的骨密度差异无统计学意义(P>0.05);(3)多因素Logistic回归分析显示:年龄可进入回归方程,而CTR联合VDR基因型组合未进入回归方程。结论(1)年龄是昆明地区T2DM伴骨质疏松患者的独立危险因素;(2)CTR联合VDR基因型与昆明地区T2DM伴骨质疏松症的遗传易感性无关。 Objective To study the relationship between calcitonin receptor(CTR),vitamin D dreceptor(VDR)gene polymorphism and type 2 diabetesmellitus(T2DM)with osteoporosis in kunming area,and to explore the pathogenesis of T2DM with osteoporosis genetic susceptibility factors.Methods We selected 237 diabetic patients in the department of endocrinology of First People’s hospital of Kunming from 2017 to 2019.(1)The enrolled patients were divided into T2DM without osteoporosis group(61 cases),T2DM with osteopenia group(111 cases),and T2DM with osteoporosis group(65 cases)by bone mineral density results.PCR-RFLP technique was used to test CTR and VDR genotypes,and the differences between the three groups of patients were compared in following indicators:CTR and VDR genotype and allele frequency,sex,age,duration of diabetes,blood pressure,height,weight,body mass index(BMI),fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),blood calcium,blood lipids,blood uric acid(UA),the concentration of vitamin D,estrogen and testosterone levels,allergic C-reactive protein(Hs-CRP),fibrinogen(FIB),oral glucose tolerance(OGTT)-0 h,2 h;0 h,2 h-insulin(INS)level and insulin resistance index(HOMA-IR).(2)The differences in the bone mineral density were compared between patients with CTR joint VDR of different genotype combinations.(3)Multiariable logistic regression analysis was performed on the indicators with statistically significant difference in CTR joint VDR genotype combinations.Results(1)Three groups of patients were compared,CTR system joint VDR had no statistically significant difference in the different genotype combinations(P>0.05).(2)Comparison of three genotype combination in CTR system joint VDR,the bone mineral density has no statistical significant difference(P>0.05).(3)Multi-factor logistic regression analysis showed that age entered the regression equation of system and CTR system joint VDR genotype combinations did not enter the regression equation.Conclusions(1)Age is an independent risk factor in the kunming area of T2DM patients with osteoporosis.(2)CTR system joint VDR genotype combinations has nothing to do with the genetic susceptibility to T2DM with osteoporosis in kunming area.
作者 牛玲 李博一 张程 马蓉 唐艳 刘方 尹利民 韩竺君 苗翠娟 张娴 NIU Ling;LI Bo-yi;ZHANG Cheng;MA Rong;TANG Yan;LIU Fang;YIN Li-min;HAN Zhu-jun;MIAO Cui-juan;ZHANG Xian(Dept.of Endocrinology,First People’s Hospital of Kunmig,Kunming Yunnan 650011,China;Dept.of Clinical Laboratory,First People’s Hospital of Kunmig,Kunming Yunnan 650011,China)
出处 《昆明医科大学学报》 CAS 2021年第11期74-80,共7页 Journal of Kunming Medical University
基金 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目[2018FE001(-098)]。
关键词 降钙素受体 维生素D受体 基因多态性 2型糖尿病 骨质疏松症 Calcitonin receptor Vitamin D receptor Gene polymorphism Type 2 diabetes mellitus Osteoporosis
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