血清抗米勒管激素水平与子痫前期的发生及其妊娠结局的相关性

The correlation of serum anti-Müllerian hormone levels with the occurrence of preeclampsia and related pregnancy outcomes

目的探讨妊娠30~32周血清抗米勒管激素(anti-Müllerian hormone,AMH)水平对子痫前期发生的预测意义及妊娠结局的相关性。方法选取104例正常妊娠者设为对照组;同期58例子痫前期孕妇设为病例组。回顾性分析两组孕30~32周血清样品,通过ELISA方法检测AMH水平,比较两组妊娠结局及母儿并发症等的差异。结果(1)对照组血清AMH水平高于病例组;(2)血清AMH值与子痫前期的发生及低出生体重儿的发生有一定的负相关性(P<0.05);(3)对照组新生儿体重大于病例组,剖宫产率低于病例组,差异有统计学意义(P<0.05);(4)妊娠结局方面,病例组发生产后出血、胎盘早剥、新生儿窒息率等与对照组相比,差异无统计学意义(P>0.05)。结论妊娠30~32周血清低AMH水平可以预测子痫前期的发生,通过严密监护可改善妊娠结局。

Objective To investigate the predictive value of serum anti-Müllerian hormone(AMH)levels in 30-32 weeks of gestation on the occurrence of pre-eclampsia and pregnancy outcomes.Methods A total of 104 normal pregnant women were selected as the control group;and 58 women with preeclampsia were chosen as the case group.The serum samples at 30-32 weeks of gestation were analyzed.ELISA kit was used to detect the level of AMH,and the differences in pregnancy outcomes and maternal-fetal complications were compared between the two groups.Results The serum AMH level in control group was higher than that in case group.The serum AMH value had a negative correlation with the occurrence of pre-eclampsia and low birth weight infants(P<0.05).The average delivery gestational age and neonatal weight of the control group were significantly greater than those of the case group(P<0.05);and the cesarean section rate in the control group was significantly lower than that in the case group(P<0.05).No significant difference were revealed in the postpartum hemorrhage,placental abruption,or neonatal asphyxia rate between case group and control group(P>0.05).Conclusion Low serum AMH levels at 30-32 weeks of gestation can be considered as a good predictor of preeclampsia,thus pregnancy outcomes could be effectively improved by close monitor.