龈沟液SOST及IL-1β水平与慢性牙周炎患者种植修复效果的相关性

Correlation of level of SOST and IL-1βin gingival crevicular fluid with effect of implant repair in chronic periodontitis patients

目的分析龈沟液骨硬化蛋白(SOST)、白细胞介素-1β(IL-1β)水平与慢性牙周炎患者种植修复效果的相关性。方法抽取河南神火集团职工总医院2018年2月至2020年2月收治的86例行种植修复治疗的慢性牙周炎患者为研究对象,术前检测所有患者龈沟液SOST、IL-1β水平,术后连续随访1年,评估治疗效果。74例种植修复成功患者纳入治疗有效组,12例种植修复失败患者纳入治疗无效组。比较两组龈沟液SOST、IL-1β水平,分析龈沟液SOST、IL-1β水平与慢性牙周炎患者种植修复治疗效果的相关性,评估龈沟液SOST、IL-1β水平对慢性牙周炎患者种植修复治疗效果的预测价值。结果治疗无效组龈沟液SOST、IL-1β水平分别为(118.44±26.45)pg/ml、(2.42±0.74)ng/ml,高于治疗有效组的(79.62±14.58)pg/ml、(0.82±0.22)ng/ml(P<0.05);组间其他资料比较差异未见统计学意义(P>0.05)。经Logistics回归分析显示,龈沟液SOST、IL-1β水平高与慢性牙周炎患者种植修复治疗无效有关(P<0.05)。绘制受试者工作特征曲线结果显示,龈沟液SOST水平预测慢性牙周炎患者种植修复治疗效果的曲线下面积(AUC)为0.785;龈沟液IL-1β水平预测慢性牙周炎患者种植修复治疗效果的AUC为0.805;龈沟液SOST、IL-1β水平联合预测慢性牙周炎患者种植修复治疗效果的AUC为0.852。结论龈沟液SOST、IL-1β水平高与慢性牙周炎患者种植修复治疗无效有关,龈沟液SOST、IL-1β水平联合检测对慢性牙周炎患者种植修复治疗效果有较高的预测价值。

Objective To analyze the correlation of levels of bone sclerostin(SOST)and interleukin-1β(IL-1β)in gingival crevicular fluid with effect of implant repair in chronic periodontitis patients.Methods Eighty-six patients with chronic periodontitis who were treated in General Hospital of Henan Shenhuo Group from February 2018 to February 2020 were selected.The levels of SOST and IL-1βin gingival crevicular fluid of all patients were measured before operation.The patients were followed up for one year after operation,and the therapeutic effect was evaluated.Seventy-four patients with successful implant repair were included in the effective group,and 12 patients with failed implant repair were included in the ineffective group.The levels of SOST and IL-1βin the two groups were compared.The correlation of level of SOST and IL-1βin gingival sulcus fluid with effect of implant repair in chronic periodontitis patients was analyzed.The predictive value of the levels of SOST and IL-1βin the treatment of chronic periodontitis was evaluated.Results The level of SOST and IL-1βin the ineffective group were(118.44±26.45)pg/ml and(2.42±0.74)ng/ml,respectively,higher than the(79.62±14.58)pg/ml and(0.82±0.22)ng/ml in the effective group(P<0.05).There was no statistical significance in other data between the groups(P>0.05).Logistic regression analysis showed that the high level of SOST and IL-1βin gingival crevicular fluid was related to the ineffective implant repair in patients with chronic periodontitis(P<0.05).The results of receiver operating characteristic curve showed that the area under the curve(AUC)of the level of SOST in gingival sulcus fluid to predict the effect of implant repair in patients with chronic periodontitis was 0.785;the AUC of the level of IL-1βin gingival sulcus fluid to predict the effect of implant repair in patients with chronic periodontitis was 0.805;and the AUC of the level of SOST combined with IL-1βin gingival sulcus fluid to predict the effect of implant repair in patients with chronic periodontitis was 0.852.Conclusions The high level of SOST and IL-1βin gingival crevicular fluid is related to the ineffective implant repair in patients with chronic periodontitis.The combined detection of the level of SOST and IL-1βin gingival sulcus fluid has a high predictive value for the treatment of chronic periodontitis.